Communication in tiny packages: Exosomes as means of tumor-stroma communication

被引：77

作者：

Dassler-Plenker, Juliane ^{[1
]}

Kuettner, Victoria ^{[1
]}

Egeblad, Mikala ^{[1
]}

机构：

[1] Cold Spring Harbor Lab, 1 Bungtown Rd, Cold Spring Harbor, NY 11724 USA

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER | 2020年 / 1873卷 / 02期

关键词：

Exosomes; Tumor-derived exosomes; Communication; Tumor microenvironment; Metastasis; Tumor-stroma; ASCITES-DERIVED EXOSOMES; BREAST-CANCER; PROSTATE-CANCER; EXTRACELLULAR VESICLES; MEMBRANE-VESICLES; MEDIATED TRANSFER; P-GLYCOPROTEIN; MELANOMA-CELLS; STEM-CELLS; DELIVERY;

D O I：

10.1016/j.bbcan.2020.188340

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Tumor-derived exosomes are nano-sized vesicles acting as mull-signal devices influencing tumor growth at local and distant sites. Exosomes are derived from the endolysosomal compartment and can shuttle diverse biomolecules like nucleic acids (microRNAs and DNA fragments), lipids, proteins, and even pharmacological compounds from a donor cell to recipient cells. The transfer of cargo to recipient cells enables tumor-derived exosomes to influence diverse cellular functions like proliferation, cell survival, and migration in recipient cells, highlighting tumor-derived exosomes as important players in communication within the tumor microenvironment and at distant sites. In this review, we discuss the mechanisms associated with exosome biogenesis and cargo sorting. In addition, we highlight the communication of tumor-derived exosomes in the tumor microenvironment during different phases of tumor development, focusing on angiogenesis, immune escape mechanisms, drug resistance, and metastasis.

引用

页数：13

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