Itraconazole-Laponite: Kinetics and mechanism of drug release

被引：98

作者：

Jung, Hyun ^{[2
]}

Kim, Hyun-Mi ^{[3
]}

Choy, Young Bin

Hwang, Seong-Ju

Choy, Jin-Ho ^{[1
]}

机构：

[1] Ewha Womans Univ, CINBM, Div Nanosci, Seoul 120750, South Korea

[2] Dongguk Univ, Dept Chem, Coll Sci, Seoul 100715, South Korea

[3] Seoul Natl Univ, Sch Chem & Mol Engn, Seoul 151742, South Korea

来源：

APPLIED CLAY SCIENCE | 2008年 / 40卷 / 1-4期

关键词：

smectite clay; iraconazole; controlled release; nanohybrid; intercalation reaction;

D O I：

10.1016/j.clay.2007.09.002

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 [物理化学]; 081704 [应用化学];

摘要：

A clay-drug nanohybrid was prepared by interfacial boundary ion exchange reaction, from which the release mechanism of a poorly water soluble drug, itraconazole, was studied systematically. The effect of cation types on drug release was investigated on the basis of a UPS 25 guide line and the effect of Laponite dissolution was also studied at pH = 1.2. To describe the release patterns, mathematical modeling was preformed using first-order, Elovich, parabolic diffusion, and power function equations. (C) 2007 Elsevier B.V. All rights reserved.

引用

页码：99 / 107

页数：9

共 39 条

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KINETICS OF SOIL CHEMICAL-REACTIONS - RELATIONSHIPS BETWEEN EMPIRICAL EQUATIONS AND DIFFUSION-MODELS [J].