Small Peptides Switch the Transcriptional Activity of Shavenbaby During Drosophila Embryogenesis

被引：285

作者：

Kondo, T. ^{[2
,3
]}

Plaza, S. ^{[1
,4
]}

Zanet, J. ^{[1
,4
]}

Benrabah, E. ^{[1
,4
]}

Valenti, P. ^{[1
,4
]}

Hashimoto, Y. ^{[2
,6
]}

Kobayashi, S. ^{[2
,5
]}

Payre, F. ^{[1
,4
]}

Kageyama, Y. ^{[2
,6
]}

机构：

[1] Univ Toulouse 3, Univ Toulouse, Ctr Dev Biol, F-31062 Toulouse, France

[2] Natl Inst Nat Sci, Okazaki Inst Integrat Biosci, Natl Inst Basic Biol, Okazaki, Aichi 4448787, Japan

[3] Nara Inst Sci & Technol, Grad Sch Biol Sci, Nara 6300192, Japan

[4] CBD, CNRS, UMR 5547, F-31062 Toulouse, France

[5] Grad Univ Adv Studies SOKENDAI, Sch Life Sci, Dept Basic Biol, Okazaki, Aichi 4448585, Japan

[6] Japan Sci & Technol Agcy, Precursory Res Embryon Sci & Technol PRESTO, Kawaguchi, Saitama 3320012, Japan

来源：

SCIENCE | 2010年 / 329卷 / 5989期

基金：

日本学术振兴会;

关键词：

POLYCISTRONIC MESSENGER-RNA; OPEN READING FRAMES; EPIDERMIS DIFFERENTIATION; GENOME; IDENTIFICATION; MORPHOGENESIS; EVOLUTION; GENES;

D O I：

10.1126/science.1188158

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

A substantial proportion of eukaryotic transcripts are considered to be noncoding RNAs because they contain only short open reading frames (sORFs). Recent findings suggest, however, that some sORFs encode small bioactive peptides. Here, we show that peptides of 11 to 32 amino acids encoded by the polished rice (pri) sORF gene control epidermal differentiation in Drosophila by modifying the transcription factor Shavenbaby (Svb). Pri peptides trigger the amino-terminal truncation of the Svb protein, which converts Svb from a repressor to an activator. Our results demonstrate that during Drosophila embryogenesis, Pri sORF peptides provide a strict temporal control to the transcriptional program of epidermal morphogenesis.

引用

页码：336 / 339

页数：4

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