Synthesis and antifungal activities of natural and synthetic biflavonoids

被引：81

作者：

Sagrera, Gabriel ^{[2
]}

Bertucci, Ana ^{[1
]}

Vazquez, Alvaro ^{[1
]}

Seoane, Gustavo ^{[1
]}

机构：

[1] Univ Republica, Fac Quim, Dept Quim Organ, Montevideo, Uruguay

[2] Univ Republica, Fac Ciencias, Dept Quim Organ, Montevideo, Uruguay

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2011年 / 19卷 / 10期

关键词：

Biflavonoids; Ullmann condensation; Antifungal activity; ASPERGILLUS-FLAVUS; HYDROGEN-BOND; FLAVONOIDS; AFLATOXIN; BIFLAVANONES; CHALCONES; CHEMISTRY; INHIBIT; ACID;

D O I：

10.1016/j.bmc.2011.04.010

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

The synthesis of some natural and synthetic biflavonoids was performed in good overall yields starting from readily available materials via high yielding aldol and Ullmann condensations. Some of these compounds, especially bichalcones, display an interesting activity against fungi, higher than that of the corresponding monomers. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：3060 / 3073

页数：14

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