High prevalence of toxinogenic Clostridium difficile in Nigerian adult HIV patients

被引：28

作者：

Onwueme, Kenolisa ^{[1
,2
]}

Fadairo, Yetunde ^{[3
]}

Idoko, Lucy ^{[3
]}

Onuh, James ^{[3
]}

Alao, Olu ^{[4
]}

Agaba, Patricia ^{[3
]}

Lawson, Lovett ^{[4
]}

Ukomadu, Chinweike ^{[1
]}

Idoko, John ^{[3
]}

机构：

[1] Brigham & Womens Hosp, Boston, MA 02115 USA

[2] Obala Fdn, Boston, MA USA

[3] Univ Jos, Teaching Hosp, AIDS Prevent Initiat Nigeria, Jos, Nigeria

[4] Zankli Med Ctr, Abuja, Nigeria

来源：

TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE | 2011年 / 105卷 / 11期

关键词：

Clostridium difficile; HIV; Sub-Saharan Africa; Nigeria; Diarrhea; DIARRHEA;

D O I：

10.1016/j.trstmh.2011.07.014

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Clostridium difficile is the most commonly identified bacterial cause of nosocomial and HIV-related diarrhea. In many developing countries, antibiotic access is unregulated. Nigeria has the third highest HIV burden worldwide. Due to perceptions of low prevalence and resource incapacity, patients with diarrhea are not tested for toxinogenic C. difficile infection (CDI). In this pilot study which included 97 HIV-positive patients at two hospitals in Nigeria, the estimated prevalence of CDI was 43% and 14% for in-patients and out-patients respectively. HIV-positive out-patients were more likely to have toxinogenic CDI than non-HIV outpatients (P=0.007, Fisher's exact test). (C) 2011 Royal Society of Tropical Medicine and Hygiene. Published by Elsevier Ltd. All rights reserved.

引用

页码：667 / 669

页数：3

共 10 条

[1]

Bartlett John G, 2007, Top HIV Med, V15, P94

[2]

Beadsworth MBJ, 2007, PREVALENCE CLOSTRIDI

[3] Tests for the diagnosis of Clostridium difficile infection: The next generation [J].

Carroll, Karen C. .

ANAEROBE, 2011, 17 (04) :170-174

[4] Epidemiology of Clostridium difficile-associated diarrhea in a Peruvian tertiary care hospital [J].

Garcia, Coralith ;

Samalvides, Frine ;

Vidal, Margot ;

Gotuzzo, Eduardo ;

Dupont, Herbert L. .

AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 2007, 77 (05) :802-805

[5] Clostridium difficile-associated diarrhea from a general hospital in Argentina [J].

Legaria, MC ;

Lumelsky, G ;

Rosetti, S .

ANAEROBE, 2003, 9 (03) :113-116

[6] Peculiarities of chronic diarrhea in Enugu, southeastern Nigeria [J].

Nwokediuko, S ;

Bojuwoye, B ;

Ozumba, UC ;

Ozoh, G .

JOURNAL OF HEALTH SCIENCE, 2002, 48 (05) :435-440

[7] PCR detection of Clostridium difficile triose phosphate isomerase (tpi), toxin A (tcdA), toxin B (tcdB), binary toxin (cdtA, cdtB), and tcdC genes in Vhembe district, South Africa [J].

Samie, Amidou ;

Obi, Chikwelu L. ;

Franasiak, Jason ;

Archbald-Pannone, Laurie ;

Bessong, Pascal O. ;

Alcantara-Warren, Cirle ;

Guerrant, Richard L. .

AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 2008, 78 (04) :577-585

[8]

Sosa A, 2005, ANTIBIOTIC POLICIES: THEORY AND PRACTICE, P593, DOI 10.1007/0-387-22852-7_31

[9] Effective detection of toxigenic Clostridium difficile by a two-step algorithm including tests for antigen and cytotoxin [J].

Ticehurst, JR ;

Aird, DZ ;

Dam, LM ;

Borek, AP ;

Hargrove, JT ;

Carroll, KC .

JOURNAL OF CLINICAL MICROBIOLOGY, 2006, 44 (03) :1145-1149

[10] Toxin production by an emerging strain of Clostridium difficile associated with outbreaks of severe disease in North America and Europe [J].

Warny, M ;

Pepin, J ;

Fang, A ;

Killgore, G ;

Thompson, A ;

Brazier, J ;

Frost, E ;

McDonald, LC .

LANCET, 2005, 366 (9491) :1079-1084

← 1 →