The light and dark sides of intestinal intraepithelial lymphocytes

被引：488

作者：

Cheroutre, Hilde ^{[1
]}

Lambolez, Florence ^{[1
]}

Mucida, Daniel ^{[2
]}

机构：

[1] La Jolla Inst Allergy & Immunol, Lab Dev Immunol, La Jolla, CA 92037 USA

[2] Rockefeller Univ, Lab Mucosal Immunol, New York, NY 10065 USA

来源：

NATURE REVIEWS IMMUNOLOGY | 2011年 / 11卷 / 07期

基金：

美国国家卫生研究院;

关键词：

DELTA-T-CELLS; INFLAMMATORY-BOWEL-DISEASE; LISTERIA-MONOCYTOGENES INFECTION; RECENT THYMIC EMIGRANTS; RECEPTOR-GAMMA-DELTA; CELIAC-DISEASE; RETINOIC-ACID; TGF-BETA; EPITHELIAL-CELLS; ALPHA-BETA;

D O I：

10.1038/nri3007

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The intraepithelial lymphocytes (IELs) that reside within the epithelium of the intestine form one of the main branches of the immune system. As IELs are located at this critical interface between the core of the body and the outside environment, they must balance protective immunity with an ability to safeguard the integrity of the epithelial barrier: failure to do so would compromise homeostasis of the organism. In this Review, we address how the unique development and functions of intestinal IELs allow them to achieve this balance.

引用

页码：445 / 456

页数：12

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