The Role of Selected Pro-Inflammatory Cytokines in Pathogenesis of Ischemic Stroke

被引：206

作者：

Pawluk, Hanna ^{[1
]}

Wozniak, Alina ^{[1
]}

Grzesk, Grzegorz ^{[2
]}

Kolodziejska, Renata ^{[1
]}

Kozakiewicz, Mariusz ^{[3
]}

Kopkowska, Ewa ^{[1
]}

Grzechowiak, Elzbieta ^{[4
]}

Kozera, Grzegorz ^{[4
,5
]}

机构：

[1] Nicolaus Copernicus Univ Torun, Coll Med Bydgoszcz, Dept Med Biol & Biochem, Fac Med, Karlowicza 24, PL-85092 Bydgoszcz, Poland

[2] Nicolaus Copernicus Univ Torun, Coll Med Bydgoszcz, Dept Cardiol 2, Fac Hlth Sci, Bydgoszcz, Poland

[3] Nicolaus Copernicus Univ Torun, Coll Med Bydgoszcz, Dept Geriatr, Div Biochem & Biogerontol,Fac Hlth Sci, Bydgoszcz, Poland

[4] Nicolaus Copernicus Univ Torun, Coll Med Bydgoszcz, Dept Neurol, Fac Med, Bydgoszcz, Poland

[5] Med Univ Gdansk, Med Stimulat Ctr, Gdansk, Poland

来源：

CLINICAL INTERVENTIONS IN AGING | 2020年 / 15卷

关键词：

cytokines; ischemic stroke; old age disease; FOCAL CEREBRAL-ISCHEMIA; NECROSIS-FACTOR-ALPHA; BLOOD BIOMARKERS; BRAIN; CHEMOKINES; INTERLEUKIN-6; RECEPTOR; INJURY; MARKERS; CELLS;

D O I：

10.2147/CIA.S233909

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

030301 [社会学]; 100201 [内科学];

摘要：

Stroke is currently one of the most common causes of death and disability in the world, and its pathophysiology is a complex process, involving the oxidative stress and inflammatory reaction. Unfortunately, no biochemical factors useful in the diagnostics and treatment of stroke have been clearly established to date. Therefore, researchers are increasingly interested in the inflammatory response triggered by cerebral ischemia and its role in the development of cerebral infarction. This article gives an overview of the available literature data concerning the role of pro-inflammatory cytokines in acute stroke. Detailed analysis of their role in cerebral circulation disturbances can also suggest certain immune response regulatory mechanisms aimed to reduce damage to the nervous tissue in the course of stroke.

引用

页码：469 / 484

页数：16

共 134 条

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The solution structure of monomeric CCL5 in complex with a doubly sulfated N-terminal segment of CCR5 [J].