Opportunities and challenges in the development of kinase inhibitor therapy for cancer

被引:147
作者
Sawyers, CL [1 ]
机构
[1] Univ Calif Los Angeles, Howard Hughes Med Inst, Los Angeles, CA 90095 USA
[2] Univ Calif Los Angeles, Dept Med, Los Angeles, CA 90095 USA
[3] Univ Calif Los Angeles, Dept Mol & Med Pharmacol, Los Angeles, CA 90095 USA
[4] Univ Calif Los Angeles, Dept Urol, Los Angeles, CA 90095 USA
[5] Univ Calif Los Angeles, Jonsson Canc Ctr, Los Angeles, CA 90095 USA
[6] Univ Calif Los Angeles, David Geffen Sch Med, Los Angeles, CA 90095 USA
关键词
D O I
10.1101/gad.1152403
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
引用
收藏
页码:2998 / 3010
页数:13
相关论文
共 101 条
[31]   Activity of a specific inhibitor of the BCR-ABL tyrosine kinase in the blast crisis of chronic myeloid leukemia and acute lymphoblastic leukemia with the philadelphia chromosome. [J].
Druker, BJ ;
Sawyers, CL ;
Kantarjian, H ;
Resta, DJ ;
Reese, SF ;
Ford, JM ;
Capdeville, R ;
Talpaz, M .
NEW ENGLAND JOURNAL OF MEDICINE, 2001, 344 (14) :1038-1042
[32]   Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells [J].
Druker, BJ ;
Tamura, S ;
Buchdunger, E ;
Ohno, S ;
Segal, GM ;
Fanning, S ;
Zimmermann, J ;
Lydon, NB .
NATURE MEDICINE, 1996, 2 (05) :561-566
[33]   Perspectives on the development of a molecularly targeted agent [J].
Druker, BJ .
CANCER CELL, 2002, 1 (01) :31-36
[34]   Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia. [J].
Druker, BJ ;
Talpaz, M ;
Resta, DJ ;
Peng, B ;
Buchdunger, E ;
Ford, JM ;
Lydon, NB ;
Kantarjian, H ;
Capdeville, R ;
Ohno-Jones, S ;
Sawyers, CL .
NEW ENGLAND JOURNAL OF MEDICINE, 2001, 344 (14) :1031-1037
[35]   Reversible tumorigenesis by MYC in hematopoietic lineages [J].
Felsher, DW ;
Bishop, JM .
MOLECULAR CELL, 1999, 4 (02) :199-207
[36]  
FORAN J, 2002, P AM SOC HEMATOLOGY, P2196
[37]  
FOTI A, 1991, BLOOD, V77, P2441
[38]   Gene-targeting reveals physiological roles and complex regulation of the phosphoinositide 3-kinases [J].
Foukas, LC ;
Okkenhaug, K .
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 2003, 414 (01) :13-18
[39]  
Frederick L, 2000, CANCER RES, V60, P1383
[40]   Phosphoinositide 3-kinase knockout mice:: role of p85α in B cell development and proliferation [J].
Fruman, DA ;
Snapper, SB ;
Yballe, CM ;
Alt, FW ;
Cantley, LC .
BIOCHEMICAL SOCIETY TRANSACTIONS, 1999, 27 (04) :624-629