Reactive Oxygen Species: The Achilles' Heel of Cancer Cells?

被引：51

作者：

Cui, Xiaojiang ^{[1
]}

机构：

[1] Cedars Sinai Med Ctr, Samuel Oschin Comprehens Canc Inst, Womens Canc Program, Dept Surg,Dept Obstet & Gynecol, Los Angeles, CA 90048 USA

来源：

ANTIOXIDANTS & REDOX SIGNALING | 2012年 / 16卷 / 11期

关键词：

D O I：

10.1089/ars.2012.4532

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Cancer development, progression, and metastasis are multistep processes. Accumulating evidence suggests that reactive oxygen species (ROS) are critically involved in cancer cell functions. This Forum reviews our current understanding of the important and paradoxical role of ROS in the regulation of tumor-associated cell properties, genes, and signaling pathways. The six reviews in this Forum showcase the up-to-date knowledge on how ROS modulate or interact with the p53 protein, epithelial-mesenchymal transition, tumor stromal cells, angiogenesis, and cancer stem cells, which are essential factors in cancer development and metastasis. The contributions demonstrate that ROS levels in cancer cells are tightly controlled, which brings promises and challenges in the development of novel ROS-targeted anticancer therapies. Further understanding of the biological mechanisms underlying the effects of oxidative stress on tumor growth and metastasis will contribute to the advancement of cancer biology and cancer treatment. Antioxid. Redox Signal. 16, 1212-1214.

引用

页码：1212 / 1214

页数：3

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