Ion channels: Structure of a molecular brake

被引：6

作者：

Sansom, MSP ^{[1
]}

机构：

[1] Univ Oxford, Dept Biochem, Lab Mol Biophys, Oxford OX1 3QU, England

来源：

CURRENT BIOLOGY | 1999年 / 9卷 / 05期

关键词：

D O I：

10.1016/S0960-9822(99)80106-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A combination of crystallographic and mutagenesis studies on the HERG K+ channel, a key determinant of cardiac excitability, has suggested how the protein's extramembraneous amino terminal domain might act as a 'molecular brake' that slows down channel deactivation. (C) Elsevier Science Ltd ISSN 0960-9822.

引用

页码：R173 / R175

页数：3

共 9 条

[1]

CARBRAL JHM, 1998, CELL, V95, P649

[2] A MOLECULAR-BASIS FOR CARDIAC-ARRHYTHMIA - HERG MUTATIONS CAUSE LONG QT SYNDROME [J].

CURRAN, ME ;

SPLAWSKI, I ;

TIMOTHY, KW ;

VINCENT, GM ;

GREEN, ED ;

KEATING, MT .

CELL, 1995, 80 (05) :795-803

[3] The structure of the potassium channel:: Molecular basis of K+ conduction and selectivity [J].

Doyle, DA ;

Cabral, JM ;

Pfuetzner, RA ;

Kuo, AL ;

Gulbis, JM ;

Cohen, SL ;

Chait, BT ;

MacKinnon, R .

SCIENCE, 1998, 280 (5360) :69-77

[4] Crystal structure of the tetramerization domain of the Shaker potassium channel [J].

Kreusch, A ;

Pfaffinger, PJ ;

Stevens, CF ;

Choe, S .

NATURE, 1998, 392 (6679) :945-948

[5] PAS: a multifunctional domain family comes to light [J].

Ponting, CP ;

Aravind, L .

CURRENT BIOLOGY, 1997, 7 (11) :R674-R677

[6] A MECHANISTIC LINK BETWEEN AN INHERITED AND AN ACQUIRED CARDIAC-ARRHYTHMIA - HERG ENCODES THE I-KR POTASSIUM CHANNEL [J].

SANGUINETTI, MC ;

JIANG, CG ;

CURRAN, ME ;

KEATING, MT .

CELL, 1995, 81 (02) :299-307

[7] Ion channels:: A first view of K+ channels in atomic glory [J].

Sansom, MSP .

CURRENT BIOLOGY, 1998, 8 (13) :R450-R452

[8]

TERGAU H, 1997, J PHYSL, V502, P537

[9] HERG, A HUMAN INWARD RECTIFIER IN THE VOLTAGE-GATED POTASSIUM CHANNEL FAMILY [J].

TRUDEAU, MC ;

WARMKE, JW ;

GANETZKY, B ;

ROBERTSON, GA .

SCIENCE, 1995, 269 (5220) :92-95

← 1 →