Correlation of Alzheimer Disease Neuropathologic Changes With Cognitive Status: A Review of the Literature

被引：1469

作者：

Nelson, Peter T. ^{[1
,2
]}

Alafuzoff, Irina ^{[4
]}

Bigio, Eileen H. ^{[5
]}

Bouras, Constantin ^{[6
]}

Braak, Heiko ^{[7
]}

Cairns, Nigel J. ^{[9
,10
]}

Castellani, Rudolph J. ^{[11
]}

Crain, Barbara J. ^{[12
,13
]}

Davies, Peter ^{[15
,16
]}

Del Tredici, Kelly ^{[7
]}

Duyckaerts, Charles ^{[17
]}

Frosch, Matthew P. ^{[18
]}

Haroutunian, Vahram ^{[20
]}

Hof, Patrick R. ^{[21
]}

Hulette, Christine M. ^{[22
,23
]}

Hyman, Bradley T. ^{[19
]}

Iwatsubo, Takeshi ^{[24
]}

Jellinger, Kurt A. ^{[25
]}

Jicha, Gregory A. ^{[1
,3
]}

Koevari, Enikoe ^{[6
]}

Kukull, Walter A. ^{[27
]}

Leverenz, James B. ^{[26
,28
,29
]}

Love, Seth ^{[30
,31
]}

Mackenzie, Ian R. ^{[32
]}

Mann, David M. ^{[33
]}

Masliah, Eliezer ^{[34
,35
]}

McKee, Ann C. ^{[36
,37
]}

Montine, Thomas J. ^{[29
]}

Morris, John C. ^{[9
]}

Schneider, Julie A.

Sonnen, Joshua A.

Thal, Dietmar R. ^{[8
]}

Trojanowski, John Q. ^{[38
]}

Troncoso, Juan C. ^{[12
,14
]}

Wisniewski, Thomas ^{[39
,40
,41
,42
]}

Woltjer, Randall L. ^{[43
]}

Beach, Thomas G. ^{[44
]}

机构：

[1] Univ Kentucky, Sanders Brown Ctr Aging, Lexington, KY 40536 USA

[2] Univ Kentucky, Dept Pathol, Lexington, KY 40536 USA

[3] Univ Kentucky, Dept Neurol, Lexington, KY 40536 USA

[4] Uppsala Univ, Dept Genet & Pathol, Rudbeck Lab, Uppsala, Sweden

[5] Northwestern Univ, Dept Pathol, NW Alzheimer Dis Ctr, Feinberg Sch Med, Chicago, IL 60611 USA

[6] Univ Geneva, Sch Med, Dept Psychiat, CH-1211 Geneva, Switzerland

[7] Univ Ulm, Dept Neurol, Sect Clin Neuroanat, D-7900 Ulm, Germany

[8] Univ Ulm, Inst Pathol, Neuropathol Lab, Ulm, Germany

[9] Washington Univ, Sch Med, Dept Neurol, St Louis, MO 63110 USA

[10] Washington Univ, Sch Med, Dept Pathol & Immunol, St Louis, MO USA

[11] Univ Maryland, Sch Med, Dept Pathol, Baltimore, MD 21201 USA

[12] Johns Hopkins Sch Med, Dept Pathol, Baltimore, MD USA

[13] Johns Hopkins Sch Med, Dept Oncol, Baltimore, MD USA

[14] Johns Hopkins Sch Med, Dept Neurol, Baltimore, MD USA

[15] Albert Einstein Univ, Dept Pathol, Feinstein Inst Med Res, Manhasset, NY USA

[16] Albert Einstein Univ, Dominick P Purpura Dept Neurosciencey, Feinstein Inst Med Res, Manhasset, NY USA

[17] Hop La Pitie Salpetriere, Serv Neuropathol Raymond Escourolle, Paris, France

[18] Harvard Univ, Massachusetts Gen Hosp, Sch Med, CS Kubik Lab Neuropathol, Boston, MA USA

[19] Harvard Univ, Sch Med, Dept Neurol, Massachusetts Gen Hosp, Boston, MA 02115 USA

[20] Mt Sinai Sch Med, Dept Psychiat, New York, NY USA

[21] Mt Sinai Sch Med, Dept Neurosci, New York, NY USA

[22] Duke Univ, Sch Med, Dept Pathol, Durham, NC 27706 USA

[23] Duke Univ, Sch Med, Dept Neurol, Durham, NC USA

[24] Univ Tokyo, Dept Neuropathol, Grad Sch Med, Tokyo, Japan

[25] Inst Clin Neurobiol, Vienna, Austria

[26] Univ Washington, VA Puget Sound Hlth Care Syst, Seattle, WA USA

[27] Univ Washington, Dept Epidemiol, Sch Publ Hlth, Seattle, WA 98195 USA

[28] Univ Washington, Sch Med, Dept Neurol, Seattle, WA USA

[29] Univ Washington, Sch Med, Dept Pathol, Seattle, WA 98195 USA

[30] Univ Bristol, Dept Neuropathol, Inst Clin Neurosci, Frenchay Hosp, Bristol, Avon, England

[31] Univ Bristol, Sch Clin Sci, Bristol, Avon, England

[32] Univ British Columbia, Dept Pathol, Vancouver, BC, Canada

[33] Univ Manchester, Hope Hosp, Dept Neuropathol, Salford M6 8HD, Lancs, England

[34] Univ Calif San Diego, Sch Med, Dept Neurosci, La Jolla, CA 92093 USA

[35] Univ Calif San Diego, Sch Med, Dept Pathol, La Jolla, CA 92093 USA

[36] Boston Univ, Dept Pathol, Bedford, MA USA

[37] Boston Univ, Bedford Vet Adm Med Ctr, Bedford, MA USA

[38] Univ Penn, Sch Med, Dept Pathol & Lab Med, Ctr Neurodegenerat Dis Res,Inst Aging, Philadelphia, PA 19104 USA

[39] NYU, Dept Pathol, Langone Med Ctr, New York, NY 10016 USA

[40] NYU, Dept Neurol, Langone Med Ctr, New York, NY 10016 USA

[41] NYU, Dept Psychiat, Langone Med Ctr, New York, NY 10016 USA

[42] NYU, Langone Med Ctr, Alzheimers Dis Ctr, New York, NY USA

[43] Oregon Hlth & Sci Univ, Dept Pathol, Portland, OR 97201 USA

[44] Banner Sun Hlth Res Inst, Civin Lab Neuropathol, Sun City, AZ USA

来源：

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY | 2012年 / 71卷 / 05期

基金：

美国国家卫生研究院; 英国医学研究理事会;

关键词：

Aging; Alzheimer disease; Amyloid; Dementia; Epidemiology; Neuropathology; MAPT; Neurofibrillary tangles; FRONTOTEMPORAL LOBAR DEGENERATION; NEUROFIBRILLARY TANGLE FORMATION; AMYOTROPHIC-LATERAL-SCLEROSIS; PAIRED HELICAL FILAMENTS; MINI-MENTAL-STATE; PARKINSONISM-DEMENTIA COMPLEX; AMYLOID CASCADE HYPOTHESIS; IMPAIR SYNAPTIC PLASTICITY; POSTERIOR CORTICAL ATROPHY; GRADED INTELLECTUAL STATUS;

D O I：

10.1097/NEN.0b013e31825018f7

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Clinicopathologic correlation studies are critically important for the field of Alzheimer disease (AD) research. Studies on human subjects with autopsy confirmation entail numerous potential biases that affect both their general applicability and the validity of the correlations. Many sources of data variability can weaken the apparent correlation between cognitive status and AD neuropathologic changes. Indeed, most persons in advanced old age have significant non-AD brain lesions that may alter cognition independently of AD. Worldwide research efforts have evaluated thousands of human subjects to assess the causes of cognitive impairment in the elderly, and these studies have been interpreted in different ways. We review the literature focusing on the correlation of AD neuropathologic changes (i.e. beta-amyloid plaques and neurofibrillary tangles) with cognitive impairment. We discuss the various patterns of brain changes that have been observed in elderly individuals to provide a perspective for understanding AD clinicopathologic correlation and conclude that evidence from many independent research centers strongly supports the existence of a specific disease, as defined by the presence of AA plaques and neurofibrillary tangles. Although AA plaques may play a key role in AD pathogenesis, the severity of cognitive impairment correlates best with the burden of neocortical neurofibrillary tangles.

引用

页码：362 / 381

页数：20

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