2,6,9-trisubstituted purines: Optimization towards highly potent and selective CDK1 inhibitors

被引：93

作者：

Imbach, P ^{[1
]}

Capraro, HG ^{[1
]}

Furet, P ^{[1
]}

Mett, H ^{[1
]}

Meyer, T ^{[1
]}

Zimmermann, J ^{[1
]}

机构：

[1] Novartis Ltd, Therapeut Area Oncol, Novartis Pharmaceut, CH-4002 Basel, Switzerland

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1999年 / 9卷 / 01期

关键词：

D O I：

10.1016/S0960-894X(98)00691-X

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Novel 2,6,9-substituted purine derivatives represent a class of potent and selective inhibitors of CDK1/cyclinB. The synthesis, SAR and biological profile of selected compounds are described, (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：91 / 96

页数：6

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