Involvement of β2-adrenergic and μ-opioid receptors in antinociception produced by intracerebroventricular administration of α,β-methylene-ATP

被引：10

作者：

Fukui, M ^{[1
]}

Nakagawa, T ^{[1
]}

Minami, M ^{[1
]}

Satoh, M ^{[1
]}

机构：

[1] Kyoto Univ, Fac Pharmaceut Sci, Dept Mol Pharmacol, Kyoto 6068501, Japan

来源：

JAPANESE JOURNAL OF PHARMACOLOGY | 2001年 / 86卷 / 04期

关键词：

alpha; beta-methylene-ATP; antinociception; beta(2)-adrenoceptor; mu-opioid receptor; intracerebroventricular;

D O I：

10.1254/jjp.86.423

中图分类号：

R9 [药学];

学科分类号：

1007 [药学];

摘要：

The present study examined what kind of receptors are involved in the antinociception produced by intracerebroventricular (i.c.v.) administration of alpha,beta -methylene-ATP using antagonists at adrenergic, serotonin or opioid receptors. Antinociceptive effect of alpha,beta -methylene-ATP (10 nmol/rat) was significantly attenuated by subcutaneous pretreatment with propranolol and naloxone, but not phentolamine or methysergide, at a dose of 10 mg/kg. I.c.v. pretreatment with propranolol (100 nmol/rat), butoxamine (100 nmol/rat), ICI-118,551 (100 nmol/rat) and naloxone (30 nmol/rat) significantly attenuated the antinociceptive effect of alpha,beta -methylene-ATP. However, i.c.v. pretreatment with atenolol (100 nmol/rat), naltrindole (30 nmol/rat) or nor-binaltorphimine (30 nmol/rat) did not show any significant effects. These results suggest that supraspinal beta (2)-adrenergic and mu -opioid receptors are involved in the antinociceptive effect of i.c.v. administered alpha,beta -methylene-ATP.

引用

页码：423 / 428

页数：6

共 36 条

[1]

STEREOSELECTIVE BLOCKADE OF CENTRAL [H-3] 5-HYDROXYTRYPTAMINE BINDING TO MULTIPLE SITES (5-HT1A, 5-HT1B AND 5-HT1C) BY MIANSERIN AND PROPRANOLOL [J].