VEGF receptor signal transduction - A brief update

被引：74

作者：

Claesson-Welsh, Lena ^{[1
]}

机构：

[1] Uppsala Univ, Dept Immunol Genet & Pathol, Rudbeck Lab, Dag Hammarskjoldsv 20, S-75185 Uppsala, Sweden

来源：

VASCULAR PHARMACOLOGY | 2016年 / 86卷

关键词：

ENDOTHELIAL-GROWTH-FACTOR; TYROSINE PHOSPHORYLATION SITES; ADAPTER PROTEIN; CELL MIGRATION; BLOOD-VESSELS; KINASE; ACTIVATION; ANGIOGENESIS; FLT-1; MICE;

D O I：

10.1016/j.vph.2016.05.011

中图分类号：

R9 [药学];

学科分类号：

100702 [药剂学];

摘要：

Vascular endothelial growth factor (VEGF) signal transduction through receptor tyrosine lcinases VEGF receptor 1, -2 and -3 is of crucial importance for monocytes/macrophages, blood vascular endothelial and lymphatic endothelial cells both in physiology and in a number of pathologies notably cancer. This brief review summarizes the current status of VEGF receptor signaling with emphasis on in vivo data. (C) 2016 Elsevier Inc All rights reserved.

引用

收藏

页码：14 / 17

页数：4

相关论文

共 59 条

[11]

Ligand-induced vascular endothelial growth factor receptor-3 (VEGFR-3) heterodimerization with VEGFR-2 in primary lymphatic endothelial cells regulates tyrosine phosphorylation sites [J].

Dixelius, J ;

Mäkinen, T ;

Wirzenius, M ;

Karkkainen, MJ ;

Wernstedt, C ;

Alitalo, K ;

Claesson-Welsh, L .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (42) :40973-40979

[12]

Cardiovascular failure in mouse embryos deficient in VEGF receptor-3 [J].

Dumont, DJ ;

Jussila, L ;

Taipale, J ;

Lymboussaki, A ;

Mustonen, T ;

Pajusola, K ;

Breitman, M ;

Alitalo, K .

SCIENCE, 1998, 282 (5390) :946-949

[13]

Discovery of vascular permeability factor (VPF) [J].

Dvorak, HF .

EXPERIMENTAL CELL RESEARCH, 2006, 312 (05) :522-526

[14]

Molecular basis for sunitinib efficacy and future clinical development [J].

Faivre, Sandrine ;

Demetri, George ;

Sargent, William ;

Raymond, Eric .

NATURE REVIEWS DRUG DISCOVERY, 2007, 6 (09) :734-745

[15]

Anti-PIGF inhibits growth of VEGF(R)-Inhibitor-Resistant tumors without affecting healthy vessels [J].

Fischer, Christian ;

Jonckx, Bart ;

Mazzone, Massimiliano ;

Zacchigna, Serena ;

Loges, Sonja ;

Pattarini, Lucia ;

Chorianopoulos, Emmanuel ;

Liesenborghs, Laurens ;

Koch, Marta ;

De Mol, Maria ;

Autiero, Monica ;

Wyns, Sabine ;

Plaisance, Stephane ;

Moons, Lieve ;

van Rooijen, Nico ;

Giacca, Mauro ;

Stassen, Jean-Marie ;

Dewerchin, Mieke ;

Collen, Desire ;

Carmeliet, Peter .

CELL, 2007, 131 (03) :463-475

[16]

ROLE OF THE FLT-1 RECEPTOR TYROSINE KINASE IN REGULATING THE ASSEMBLY OF VASCULAR ENDOTHELIUM [J].

FONG, GH ;

ROSSANT, J ;

GERTSENSTEIN, M ;

BREITMAN, ML .

NATURE, 1995, 376 (6535) :66-70

[17]

Endothelial Cell Adhesion to the Extracellular Matrix Induces c-Src-Dependent VEGFR-3 Phosphorylation Without the Activation of the Receptor Intrinsic Kinase Activity [J].

Galvagni, Federico ;

Pennacchini, Susanna ;

Salameh, Ahmad ;

Rocchigiani, Marina ;

Neri, Francesco ;

Orlandini, Maurizio ;

Petraglia, Felice ;

Gotta, Stefano ;

Sardone, Gian Luca ;

Matteucci, Giacomo ;

Terstappen, Georg C. ;

Oliviero, Salvatore .

CIRCULATION RESEARCH, 2010, 106 (12) :1839-U125

[18]

VEGF controls endothelial-cell permeability by promoting the β-arrestin-dependent endocytosis of VE-cadherin [J].

Gavard, Julie ;

Gutkind, J. Silvio .

NATURE CELL BIOLOGY, 2006, 8 (11) :1223-U17

[19]

Gerber HP, 1999, DEVELOPMENT, V126, P1149

[20]

A repressor sequence in the juxtamembrane domain of Flt-1 (VEGFR-1) constitutively inhibits vascular endothelial growth factor-dependent phosphatidylinositol 3′-kinase activation and endothelial cell migration [J].

Gille, H ;

Kowalski, J ;

Yu, LL ;

Chen, H ;

Pisabarro, MT ;

Davis-Smyth, T ;

Ferrara, N .

EMBO JOURNAL, 2000, 19 (15) :4064-4073

← 1 2 3 4 5 6 →