Effect of changing polymer chain length on the target-mediated agglutination of polymer-grafted nanoparticles

被引：5

作者：

Costanzo, Philip J. ^{[1
]}

Dan, Nily ^{[2
]}

Lancaster, Katherine S. ^{[1
]}

Lebrilla, Carlito B. ^{[1
]}

Patten, Timothy E. ^{[1
]}

机构：

[1] Univ Calif Davis, Dept Chem, Davis, CA 95616 USA

[2] Drexel Univ, Dept Biol & Chem Engn, Philadelphia, PA 19104 USA

来源：

MACROMOLECULES | 2008年 / 41卷 / 04期

关键词：

D O I：

10.1021/ma7021343

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

The preparation and agglutination of poly(ethylene glycol) (PEG) grafted SiO2 nanoparticles with biotin chain ends were studied to investigate the effect of varying molecular weight of the PEG chain on the behavior of the system. Nuclear magnetic resonance (NMR) spectrum studies of polymer show that the signal due to the methylene unit adjacent to the azido chain end overlaps with the backbone methylene signals. The avidin concentration is found to be proportional to the number of biotin chains in the system and is found that the larger the number of functionalized chains per particle, the higher the number of avidin molecules required to induce aggregation. The end-grafted polymer layers are found to possess uniform chain stretching, where all chain ends are located at the outer brush edge.

引用

页码：1570 / 1576

页数：7

共 20 条

[1] Organization of 'nanocrystal molecules' using DNA [J].