Effect sf changes in action potential shape on calcium currents and transmitter release in a calyx-type synapse of the rat auditory brainstem

被引：132

作者：

Borst, JGG ^{[1
]}

Sakmann, B ^{[1
]}

机构：

[1] Max Planck Inst Med Res, Zellphysiol Abt, D-69120 Heidelberg, Germany

来源：

PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES | 1999年 / 354卷 / 1381期

关键词：

calcium current; presynaptic terminal; voltage clamp; calcium domain; action potential; calyx of Held;

D O I：

10.1098/rstb.1999.0386

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We studied the relation between the size of presynaptic calcium influx and transmitter release by making simultaneous voltage clamp recordings from presynaptic terminals, the calyces of Held and postsynaptic cells, the principal cells of the medial nucleus of the trapezoid body, in slices of the rat brainstem. Calyces were voltage clamped with different action potential waveforms. The amplitude of the excitatory postsynaptic currents depended supralinearly on the size of the calcium influx, in the absence of changes in the time-course of the calcium influx. This result is in agreement with the view that at this synapse most vesicles are released by the combined action of multiple calcium channels.

引用

页码：347 / 355

页数：9

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