Antimitotic diterpenoids from Erythropodium caribaeorum:: isolation artifacts and putative biosynthetic intermediates

被引：31

作者：

Britton, R

Roberge, M

Berisch, H

Andersen, RJ

机构：

[1] Univ British Columbia, Dept Chem, Vancouver, BC V6T 1Z1, Canada

[2] Univ British Columbia, Dept Oceanog EOS, Vancouver, BC V6T 1Z1, Canada

[3] Univ British Columbia, Dept Biochem & Mol Biol, Vancouver, BC V6T 1Z3, Canada

来源：

TETRAHEDRON LETTERS | 2001年 / 42卷 / 16期

基金：

加拿大自然科学与工程研究理事会;

关键词：

D O I：

10.1016/S0040-4039(01)00347-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Two new natural products, caribaeorane (12) and 15-hydroxycaribaeorane (11), have been identified in Erythropodium caribaeorum extracts by isolation of their C-4 methylketals 10 and 9. It has been demonstrated that eleutherobin (1) is an isolation artifact. A proposal for the late stages of the biosynthetic pathway to the E. calibaeorum antimitotic diterpenoids is presented. (C) 2001 Published by Elsevier Science Ltd.

引用

页码：2953 / 2956

页数：4

共 6 条

[1] Antimitotic diterpenes from Erythropodium caribaeorum test pharmacophore models for microtubule stabilization [J].