Questioning the paradigm of metal complex promoted phosphodiester hydrolysis:: [Mo7O24]6- polyoxometalate cluster as an unlikely catalyst for the hydrolysis of a DNA model substrate

被引：66

作者：

Cartuyvels, Els ^{[1
]}

Absillis, Gregory ^{[1
]}

Parac-Vogt, Tatjana N. ^{[1
]}

机构：

[1] Katholieke Univ Leuven, Dept Chem, B-3001 Louvain, Belgium

来源：

CHEMICAL COMMUNICATIONS | 2008年 / 01期

关键词：

D O I：

10.1039/b714860g

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The first example of a phosphodiester bond cleavage promoted by a highly negatively charged polyoxometalate cluster has been discovered: the hydrolysis of the phosphodiester bond in a DNA model substrate bis(p-nitrophenyl) phosphate (BNPP) is promoted by the heptamolybdate anion [Mo7O24](6-) with rates which represent an acceleration of nearly four orders of magnitude compared to the uncatalyzed cleavage.

引用

页码：85 / 87

页数：3

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