Hormonal effects on the brain

被引：100

作者：

Woolley, CS

Schwartzkroin, PA

机构：

[1] Northwestern Univ, Dept Neurobiol & Physiol, Evanston, IL 60208 USA

[2] Univ Washington, Dept Neurol Surg, Seattle, WA 98195 USA

[3] Univ Washington, Dept Physiol Biophys, Seattle, WA 98195 USA

来源：

EPILEPSIA | 1998年 / 39卷

关键词：

NMDA receptors; estradiol; progesterone; hippocampus; seizures;

D O I：

10.1111/j.1528-1157.1998.tb02601.x

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Changes in seizure frequency over the course of the menstrual cycle (i.e., catamenial epilepsy) have long been documented. Ovarian steroid hormones have a number of important short- and long-term effects on the brain that may contribute to this phenomenon. In particular, estrogen induces structural and functional changes in hippocampal neurons which may contribute significantly to increasing seizure susceptibility. This article reviews the mechanisms of action of steroid hormones on the basis of findings in animal models, with particular emphasis on the effects of estrogen on the hippocampus.

引用

收藏

页码：S2 / S8

页数：7

相关论文

共 45 条

[11] DISTRIBUTION OF CELLS CONTAINING PROGESTERONE-RECEPTOR MESSENGER-RNA IN THE FEMALE RAT DICEPHALON AND TELENCEPHALON - AN INSITU HYBRIDIZATION STUDY [J].

HAGIHARA, K ;

HIRATA, S ;

OSADA, T ;

HIRAI, M ;

KATO, J .

MOLECULAR BRAIN RESEARCH, 1992, 14 (03) :239-249

[12] DENDRITIC SPINES - CELLULAR SPECIALIZATIONS IMPARTING BOTH STABILITY AND FLEXIBILITY TO SYNAPTIC FUNCTION [J].

HARRIS, KM ;

KATER, SB .

ANNUAL REVIEW OF NEUROSCIENCE, 1994, 17 :341-371

[13]

JOELS M, 1995, J NEUROSCI, V15, P4289

[14] THE EFFECT OF PROGESTERONE AND ITS METABOLITES ON THE INTERICTAL EPILEPTIFORM DISCHARGE IN THE CATS CEREBRAL-CORTEX [J].

LANDGREN, S ;

AASLY, J ;

BACKSTROM, T ;

DUBROVSKY, B ;

DANIELSSON, E .

ACTA PHYSIOLOGICA SCANDINAVICA, 1987, 131 (01) :33-42

[15] EFFECT OF PROGESTERONE ON SPONTANEOUS INTERICTAL SPIKE EVOKED BY APPLICATION OF PENICILLIN TO CATS CEREBRAL-CORTEX [J].

LANDGREN, S ;

BACKSTROM, T ;

KALISTRATOV, G .

JOURNAL OF THE NEUROLOGICAL SCIENCES, 1978, 36 (01) :119-133

[16] Distribution of estrogen receptor-beta-like immunoreactivity in rat forebrain [J].

Li, X ;

Schwartz, PE ;

Rissman, EF .

NEUROENDOCRINOLOGY, 1997, 66 (02) :63-67

[17] SEIZURE CIRCUITS IN THE HIPPOCAMPUS AND ASSOCIATED STRUCTURES [J].

LOTHMAN, EW .

HIPPOCAMPUS, 1994, 4 (03) :286-290

[18] KAINIC ACID-INDUCED LIMBIC SEIZURES - METABOLIC, BEHAVIORAL, ELECTROENCEPHALOGRAPHIC AND NEUROPATHOLOGICAL CORRELATES [J].

LOTHMAN, EW ;

COLLINS, RC .

BRAIN RESEARCH, 1981, 218 (1-2) :299-318

[19] AUTORADIOGRAPHIC LOCALIZATION OF ESTRADIOL-BINDING NEURONS IN THE RAT HIPPOCAMPAL-FORMATION AND ENTORHINAL CORTEX [J].

LOY, R ;

GERLACH, JL ;

MCEWEN, BS .

DEVELOPMENTAL BRAIN RESEARCH, 1988, 39 (02) :245-251

[20] NEUROSTEROIDS - ENDOGENOUS BIMODAL MODULATORS OF THE GABA-A RECEPTOR - MECHANISM OF ACTION AND PHYSIOLOGICAL SIGNIFICANCE [J].

MAJEWSKA, MD .

PROGRESS IN NEUROBIOLOGY, 1992, 38 (04) :379-395

← 1 2 3 4 5 →