Virulence factors of Helicobacter pylori:: implications for vaccine development

被引：20

作者：

Suerbaum, S ^{[1
]}

Josenhans, C ^{[1
]}

机构：

[1] Ruhr Univ Bochum, Abt Med Mikrobiol, D-44780 Bochum, Germany

来源：

MOLECULAR MEDICINE TODAY | 1999年 / 5卷 / 01期

关键词：

D O I：

10.1016/S1357-4310(98)01390-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Helicobacter pylori is one of the most common infectious diseases in humans and causes gastritis, peptic ulcer disease and malignant tumours of the stomach. This review discusses how H. pylori can colonize the human stomach, an ecological niche that is protected against all other bacteria. Knowledge about the virulence factors of H. pylori has accumulated rapidly over the last decade. Together with the information contained in the complete H. pylori genome sequence, this knowledge is now being applied in the search for a Vaccine against this global pathogen.

引用

页码：32 / 39

页数：8

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