Virulence factors of Helicobacter pylori:: implications for vaccine development

被引：20

作者：

Suerbaum, S ^{[1
]}

Josenhans, C ^{[1
]}

机构：

[1] Ruhr Univ Bochum, Abt Med Mikrobiol, D-44780 Bochum, Germany

来源：

MOLECULAR MEDICINE TODAY | 1999年 / 5卷 / 01期

关键词：

D O I：

10.1016/S1357-4310(98)01390-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Helicobacter pylori is one of the most common infectious diseases in humans and causes gastritis, peptic ulcer disease and malignant tumours of the stomach. This review discusses how H. pylori can colonize the human stomach, an ecological niche that is protected against all other bacteria. Knowledge about the virulence factors of H. pylori has accumulated rapidly over the last decade. Together with the information contained in the complete H. pylori genome sequence, this knowledge is now being applied in the search for a Vaccine against this global pathogen.

引用

页码：32 / 39

页数：8

共 53 条

[21]

Feldman RA, 1998, BRIT MED BULL, V54, P39

[22] RECOMBINANT ANTIGENS PREPARED FROM THE UREASE SUBUNITS OF HELICOBACTER SPP - EVIDENCE OF PROTECTION IN A MOUSE MODEL OF GASTRIC INFECTION [J].

FERRERO, RL ;

THIBERGE, JM ;

HUERRE, M ;

LABIGNE, A .

INFECTION AND IMMUNITY, 1994, 62 (11) :4981-4989

[23] THE GROES HOMOLOG OF HELICOBACTER-PYLORI CONFERS PROTECTIVE IMMUNITY AGAINST MUCOSAL INFECTION IN MICE [J].

FERRERO, RL ;

THIBERGE, JM ;

KANSAU, I ;

WUSCHER, N ;

HUERRE, M ;

LABIGNE, A .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (14) :6499-6503

[24] Therapeutic intragastric vaccination against Helicobacter pylori in mice eradicates an otherwise chronic infection and confers protection against reinfection [J].

Ghiara, P ;

Rossi, M ;

Marchetti, M ;

DiTommaso, A ;

Vindigni, C ;

Ciampolini, F ;

Covacci, A ;

Telford, JL ;

DeMagistris, MT ;

Pizza, M ;

Rappuoli, R ;

DelGiudice, G .

INFECTION AND IMMUNITY, 1997, 65 (12) :4996-5002

[25] Protection of mice against gastric colonization by Helicobacter pylori by single oral dose immunization with attenuated Salmonella typhimurium producing urease subunits A and B [J].

Gómez-Duarte, OG ;

Lucas, B ;

Yan, ZX ;

Panthel, K ;

Haas, R ;

Meyer, TF .

VACCINE, 1998, 16 (05) :460-471

[26] Systemic immunization with urease protects mice against Helicobacter pylori infection [J].

Guy, B ;

Hessler, C ;

Fourage, S ;

Haensler, J ;

Vialon-Lafay, E ;

Rokbi, B ;

Millet, MJQ .

VACCINE, 1998, 16 (08) :850-856

[27] Helicobacter pylori adhesin binding fucosylated histo-blood group antigens revealed by retagging [J].

Ilver, D ;

Arnqvist, A ;

Ögren, J ;

Frick, IM ;

Kersulyte, D ;

Incecik, ET ;

Berg, DE ;

Covacci, A ;

Engstrand, L ;

Borén, T .

SCIENCE, 1998, 279 (5349) :373-377

[28] COMPARATIVE ULTRASTRUCTURAL AND FUNCTIONAL-STUDIES OF HELICOBACTER-PYLORI AND HELICOBACTER-MUSTELAE FLAGELLIN MUTANTS - BOTH FLAGELLIN SUBUNITS, FLAA AND FLAB, ARE NECESSARY FOR FULL MOTILITY IN HELICOBACTER SPECIES [J].

JOSENHANS, C ;

LABIGNE, A ;

SUERBAUM, S .

JOURNAL OF BACTERIOLOGY, 1995, 177 (11) :3010-3020

[29] Meaning and therapeutic potential of microbial recognition of host glycoconjugates [J].

Karlsson, KA .

MOLECULAR MICROBIOLOGY, 1998, 29 (01) :1-11

[30]

KERSULYTE D, IN PRESS MOL MICROBI

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