Microarrays for studying the host transcriptional response to microbial infection and for the identification of host drug targets

被引：14

作者：

Yowe, D ^{[1
]}

Cook, WJ ^{[1
]}

Gutierrez-Ramos, JC ^{[1
]}

机构：

[1] Millennium Pharmaceut Inc, Cambridge, MA 02139 USA

来源：

MICROBES AND INFECTION | 2001年 / 3卷 / 10期

关键词：

microarray; host-pathogen interaction; infection; transcriptional profiling; drug targets;

D O I：

10.1016/S1286-4579(01)01439-3

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

It is essential to understand the molecular basis of a host's response to microbial infection so that disease and tissue damage can be prevented. Modulation of host RNA expression is a critical set of molecular changes that occur upon infection. Global analysis of gene expression should provide an understanding of host RNA transcriptional changes that occur upon host-pathogen interaction. This series of articles focuses on the use of microarrays for analyzing the transcriptional response of a host to microbial infection and for drug target identification. (C) 2001 Editions scientifiques et medicales Elsevier SAS.

引用

收藏

页码：813 / 821

页数：9

相关论文

共 39 条

[1] Broad patterns of gene expression revealed by clustering analysis of tumor and normal colon tissues probed by oligonucleotide arrays [J].

Alon, U ;

Barkai, N ;

Notterman, DA ;

Gish, K ;

Ybarra, S ;

Mack, D ;

Levine, AJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (12) :6745-6750

[2] Microarray analysis identifies interferon-inducible genes and Stat-1 as major transcriptional targets of human papillomavirus type 31 [J].

Chang, YJE ;

Laimins, LA .

JOURNAL OF VIROLOGY, 2000, 74 (09) :4174-4182

[3] Accessing genetic information with high-density DNA arrays [J].

Chee, M ;

Yang, R ;

Hubbell, E ;

Berno, A ;

Huang, XC ;

Stern, D ;

Winkler, J ;

Lockhart, DJ ;

Morris, MS ;

Fodor, SPA .

SCIENCE, 1996, 274 (5287) :610-614

[4] Monitoring cellular responses to Listeria monocytogenes with oligonucleotide arrays [J].

Cohen, P ;

Bouaboula, M ;

Bellis, M ;

Baron, V ;

Jbilo, O ;

Poinot-Chazel, C ;

Galiègue, S ;

Hadibi, EH ;

Casellas, P .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (15) :11181-11190

[5]

CORTESE JD, 2000, SCIENTIST 0904, P26

[6] Using DNA microarrays to study host-microbe interactions [J].

Cummings, CA ;

Relman, DA .

EMERGING INFECTIOUS DISEASES, 2000, 6 (05) :513-525

[7] Expression profiling using cDNA microarrays [J].

Duggan, DJ ;

Bittner, M ;

Chen, YD ;

Meltzer, P ;

Trent, JM .

NATURE GENETICS, 1999, 21 (Suppl 1) :10-14

[8] Analysis by high density cDNA arrays of altered gene expression in human intestinal epithelial cells in response to infection with the invasive enteric bacteria Salmonella [J].

Eckmann, L ;

Smith, JR ;

Housley, MP ;

Dwinell, MB ;

Kagnoff, MF .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (19) :14084-14094

[9] Cluster analysis and display of genome-wide expression patterns [J].

Eisen, MB ;

Spellman, PT ;

Brown, PO ;

Botstein, D .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (25) :14863-14868

[10] Microarray technology - enhanced versatility, persistent challenge [J].

Epstein, CB ;

Butow, RA .

CURRENT OPINION IN BIOTECHNOLOGY, 2000, 11 (01) :36-41

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