RETRACTED: Cardiac release of urocortin precedes the occurrence of irreversible myocardial damage in the rat heart exposed to ischemia/reperfusion injury (Retracted article. See vol. 592, pg. 657, 2018)

被引：26

作者：

Knight, Richard A. ^{[1
]}

Chen-Scarabelli, Carol ^{[2
]}

Yuan, Zhaokan ^{[3
]}

McCauley, Roy B. ^{[3
]}

Di Rezze, J. ^{[3
]}

Scarabelli, Gabriele M. ^{[3
]}

Townsend, Paul A. ^{[1
]}

Latchman, David ^{[1
]}

Saravolatz, Louis ^{[3
]}

Faggian, Giuseppe ^{[4
]}

Mazzueco, Alessandro ^{[4
]}

Chowdrey, Hardial S. ^{[5
]}

Stephanou, Anastasis ^{[1
]}

Scarabelli, Tiziano M. ^{[3
]}

机构：

[1] UCL, Med Mol Biol Unit, Inst Child Hlth, London WC1N 1EH, England

[2] Univ Michigan, Div Cardiol Veteran Affairs Ann Arbor, Ann Arbor, MI 48109 USA

[3] Wayne State Univ, Sch Med, Div Cardiovasc Dis, Dept Internal Med, Detroit, MI USA

[4] Univ Verona, Div Cardiochirurg, I-37100 Verona, Italy

[5] Univ Westminster, Dept Biomed Sci, London W1W 6UW, England

来源：

FEBS LETTERS | 2008年 / 582卷 / 06期

关键词：

sublethal ischemia; biomarker; apoptosis; urocortin;

D O I：

10.1016/j.febslet.2008.02.035

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

This study evaluates whether cardiac ischemia induces release of urocortin, before and independently from myocyte cell death. Urocortin levels rose after 5-min ischemia and peaked after 10-min ischemia, when cell death was not detected. However, myocyte apoptosis and/or necrosis occurred following 20- and 30-min ischemia, which paralleled a fall in urocortin levels, suggesting that urocortin expression and release are mainly sustained by metabolically challenged, though still viable myocytes. Hence, since cardiac release of urocortin, unlike that of conventional biomarkers, occurs before and apart from cell death, urocortin levels may be clinically useful in the diagnosis of sublethal myocardial ischemia. (C) 2008 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

引用

页码：984 / 990

页数：7

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