Defense strategies and immunity-related genes

被引：130

作者：

Trowsdale, J

Parham, P

机构：

[1] Univ Cambridge, Dept Pathol, Cambridge CB2 1QP, England

[2] Univ Cambridge, Cambridge Inst Med Res, Cambridge, England

[3] Stanford Univ, Dept Biol Struct, Stanford, CA 94305 USA

来源：

EUROPEAN JOURNAL OF IMMUNOLOGY | 2004年 / 34卷 / 01期

基金：

英国医学研究理事会;

关键词：

genetics; immunity; defense; infection;

D O I：

10.1002/eji.200324693

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The immune system is of crucial importance in defense against infection. It has to cope with a large number of different pathogens that relentlessly develop new ways to avoid recognition or elimination. Yet most infections are cleared. Immune-system genes must evolve to keep pace with increasingly sophisticated evasion by pathogens. In this article we examine features of human defense genes that reflect the demands imposed by such intense selection. Key examples are MHC and KIR genes, where features such as polygeny and polymorphism facilitate the comprehensive logistics needed to counteract infection.

引用

收藏

页码：7 / 17

页数：11

相关论文

共 94 条

[1] Haplotype-specific linkage disequilibrium patterns define the genetic topography of the human MHC [J].

Ahmad, T ;

Neville, M ;

Marshall, SE ;

Armuzzi, A ;

Mulcahy-Hawes, K ;

Crawshaw, J ;

Sato, H ;

Ling, KL ;

Barnardo, M ;

Goldthorpe, S ;

Walton, R ;

Bunce, M ;

Jewell, DP ;

Welsh, KI .

HUMAN MOLECULAR GENETICS, 2003, 12 (06) :647-656

[2] Self-organized living systems:: conjunction of a stable organization with chaotic fluctuations in biological space-time [J].

Auffray, C ;

Imbeaud, S ;

Roux-Rouquié, M ;

Hood, L .

PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY OF LONDON SERIES A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES, 2003, 361 (1807) :1125-1139

[3] Membrane proteins with immunoglobulin-like domains - a master superfamily of interaction molecules [J].

Barclay, AN .

SEMINARS IN IMMUNOLOGY, 2003, 15 (04) :215-223

[4] Members of the immunoglobulin superfamily in bacteria [J].

Bateman, A ;

Eddy, SR ;

Chothia, C .

PROTEIN SCIENCE, 1996, 5 (09) :1939-1941

[5] Killer cell Ig-like receptor and leukocyte Ig-like receptor transgenic mice exhibit tissue- and cell-specific transgene expression [J].

Belkin, D ;

Torkar, M ;

Chang, CW ;

Barten, R ;

Tolaini, M ;

Haude, A ;

Allen, R ;

Wilson, MJ ;

Kioussis, D ;

Trowsdale, J .

JOURNAL OF IMMUNOLOGY, 2003, 171 (06) :3056-3063

[6] Multiple roles of major urinary proteins in the house mouse, Mus domesticus [J].

Beynon, RJ ;

Hurst, JL .

BIOCHEMICAL SOCIETY TRANSACTIONS, 2003, 31 :142-146

[7] ANTIGENIC VARIATION IN MALARIA [J].

BORST, P ;

BITTER, W ;

MCCULLOCH, R ;

VANLEEUWEN, F ;

RUDENKO, G .

CELL, 1995, 82 (01) :1-4

[8] DNA methylation maintains allele-specific KTR gene expression in human natural killer cells [J].

Chan, HW ;

Kurago, ZB ;

Stewart, CA ;

Wilson, MJ ;

Martin, MP ;

Mace, BE ;

Carrington, M ;

Trowsdale, J ;

Lutz, CT .

JOURNAL OF EXPERIMENTAL MEDICINE, 2003, 197 (02) :245-255

[9] ALLELIC INACTIVATION REGULATES OLFACTORY RECEPTOR GENE-EXPRESSION [J].

CHESS, A ;

SIMON, I ;

CEDAR, H ;

AXEL, R .

CELL, 1994, 78 (05) :823-834

[10] GENERATION OF ALLOSPECIFIC NATURAL-KILLER-CELLS BY STIMULATION ACROSS A POLYMORPHISM OF HLA-C [J].

COLONNA, M ;

BROOKS, EG ;

FALCO, M ;

FERRARA, GB ;

STROMINGER, JL .

SCIENCE, 1993, 260 (5111) :1121-1124

← 1 2 3 4 5 6 7 8 9 10 →