Defense strategies and immunity-related genes

被引：131

作者：

Trowsdale, J

Parham, P

机构：

[1] Univ Cambridge, Dept Pathol, Cambridge CB2 1QP, England

[2] Univ Cambridge, Cambridge Inst Med Res, Cambridge, England

[3] Stanford Univ, Dept Biol Struct, Stanford, CA 94305 USA

来源：

EUROPEAN JOURNAL OF IMMUNOLOGY | 2004年 / 34卷 / 01期

基金：

英国医学研究理事会;

关键词：

genetics; immunity; defense; infection;

D O I：

10.1002/eji.200324693

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The immune system is of crucial importance in defense against infection. It has to cope with a large number of different pathogens that relentlessly develop new ways to avoid recognition or elimination. Yet most infections are cleared. Immune-system genes must evolve to keep pace with increasingly sophisticated evasion by pathogens. In this article we examine features of human defense genes that reflect the demands imposed by such intense selection. Key examples are MHC and KIR genes, where features such as polygeny and polymorphism facilitate the comprehensive logistics needed to counteract infection.

引用

收藏

页码：7 / 17

页数：11

相关论文

共 94 条

[41] Single nucleotide polymorphisms in innate immunity genes: abundant variation and potential role in complex human disease [J].

Lazarus, R ;

Vercelli, D ;

Palmer, LJ ;

Klimecki, WJ ;

Silverman, EK ;

Richter, B ;

Riva, A ;

Ramoni, M ;

Martinez, FD ;

Weiss, ST ;

Kwiatkowski, DJ .

IMMUNOLOGICAL REVIEWS, 2002, 190 (01) :9-25

[42] Functional expression of murine V213 pheromone receptors involves selective association with the M10 and M1 families of MHC class Ib molecules [J].

Loconto, J ;

Papes, F ;

Chang, E ;

Stowers, L ;

Jones, EP ;

Takada, T ;

Kumánovics, A ;

Lindahl, KF ;

Dulac, C .

CELL, 2003, 112 (05) :607-618

[43] Evolution of natural killer cell receptors:: coexistence of functional Ly49 and KIR genes in baboons [J].

Mager, DL ;

McQueen, KL ;

Wee, V ;

Freeman, JD .

CURRENT BIOLOGY, 2001, 11 (08) :626-630

[44]

Marsh SG, 2000, HLA FACTSBOOK

[45] Cutting edge:: Expansion of the KIR locus by unequal crossing over [J].

Martin, MP ;

Bashirova, A ;

Traherne, J ;

Trowsdale, J ;

Carrington, M .

JOURNAL OF IMMUNOLOGY, 2003, 171 (05) :2192-2195

[46]

Martin MP, 2002, NAT GENET, V31, P429, DOI 10.1038/ng934

[47] Susceptibility to psoriatic arthritis: Influence of activating killer Ig-like receptor genes in the absence of specific HLA-C alleles [J].

Martin, MP ;

Nelson, G ;

Lee, JH ;

Pellett, F ;

Gao, XJ ;

Wade, J ;

Wilson, MJ ;

Trowsdale, J ;

Gladman, D ;

Carrington, M .

JOURNAL OF IMMUNOLOGY, 2002, 169 (06) :2818-2822

[48] The Toll receptor family and microbial recognition [J].

Medzhitov, R ;

Janeway, C .

TRENDS IN MICROBIOLOGY, 2000, 8 (10) :452-456

[49] Clusters of resistance genes in plants evolve by divergent selection and a birth-and-death process [J].

Michelmore, RW ;

Meyers, BC .

GENOME RESEARCH, 1998, 8 (11) :1113-1130

[50] HLA B*5701 is highly associated with restriction of virus replication in a subgroup of HIV-infected long term nonprogressors [J].

Migueles, SA ;

Sabbaghian, MS ;

Shupert, WL ;

Bettinotti, MP ;

Marincola, FM ;

Martino, L ;

Hallahan, CW ;

Selig, SM ;

Schwartz, D ;

Sullivan, J ;

Connors, M .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (06) :2709-2714

← 1 2 3 4 5 6 7 8 9 10 →