Ypt and Rab GTPases: insight into functions through novel interactions

被引:239
作者
Segev, N [1 ]
机构
[1] Univ Illinois, Dept Biol Sci, Mol Biol Lab, Chicago, IL 60607 USA
关键词
D O I
10.1016/S0955-0674(00)00242-8
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Ypt/Rab GTPases are key regulators of vesicular transport in eukaryotic cells. During the past two years, a number of new Ypt/Rab-interacting proteins have been identified and shown to serve as either upstream regulators or downstream effecters. Proteins that interact with these regulators and effectors of Ypt/Rabs have also been identified, and together they provide new insights into Ypt/Rab mechanisms of action. The picture that emerges from these studies suggests that Ypt/Rabs function in multiple and diverse aspects of vesicular transport. In addition, not only are Ypt/Rabs highly conserved, but their functions and interactions are as well. Interestingly, crosstalk among Ypt/Rabs and between Ypt/Rabs and other signaling factors, suggest the possibility of coordination of the individual vesicular transport steps and of the protein transport machinery with other cellular processes.
引用
收藏
页码:500 / 511
页数:16
相关论文
共 90 条
  • [1] Two new members of a family of Ypt/Rab GTPase activating proteins - Promiscuity of substrate recognition
    Albert, S
    Gallwitz, D
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (47) : 33186 - 33189
  • [2] Msb4p, a protein involved in Cdc42p-dependent organization of the actin cytoskeleton, is a Ypt/Rab-specific GAP
    Albert, S
    Gallwitz, D
    [J]. BIOLOGICAL CHEMISTRY, 2000, 381 (5-6) : 453 - 456
  • [3] Rab1 recruitment of p115 into a cis-SNARE complex: Programming budding COPII vesicles for fusion
    Allan, BB
    Moyer, BD
    Balch, WE
    [J]. SCIENCE, 2000, 289 (5478) : 444 - 448
  • [4] The p115-interactive proteins GM130 and giantin participate in endoplasmic reticulum-Golgi traffic
    Alvarez, C
    Garcia-Mata, R
    Hauri, HP
    Sztul, E
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (04) : 2693 - 2700
  • [5] The Sar1 GTPase coordinates biosynthetic cargo selection with endoplasmic reticulum export site assembly
    Aridor, M
    Fish, KN
    Bannykh, S
    Weissman, J
    Roberts, TH
    Lippincott-Schwartz, J
    Balch, WE
    [J]. JOURNAL OF CELL BIOLOGY, 2001, 152 (01) : 213 - 229
  • [6] How do Rab proteins function in membrane traffic?
    Armstrong, J
    [J]. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 2000, 32 (03) : 303 - 307
  • [7] THE GTP-BINDING PROTEIN YPT1 IS REQUIRED FOR TRANSPORT INVITRO - THE GOLGI-APPARATUS IS DEFECTIVE IN YPT1 MUTANTS
    BACON, RA
    SALMINEN, A
    RUOHOLA, H
    NOVICK, P
    FERRONOVICK, S
    [J]. JOURNAL OF CELL BIOLOGY, 1989, 109 (03) : 1015 - 1022
  • [8] GTP-BINDING YPT1 PROTEIN AND CA-2+ FUNCTION INDEPENDENTLY IN A CELL-FREE PROTEIN-TRANSPORT REACTION
    BAKER, D
    WUESTEHUBE, L
    SCHEKMAN, R
    BOTSTEIN, D
    SEGEV, N
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (01) : 355 - 359
  • [9] Epidermal growth factor and membrane trafficking: EGF receptor activation of endocytosis requires Rab5a
    Barbieri, MA
    Roberts, RL
    Gumusboga, A
    Highfield, H
    Alvarez-Dominguez, C
    Wells, A
    Stahl, PD
    [J]. JOURNAL OF CELL BIOLOGY, 2000, 151 (03) : 539 - 550
  • [10] TRAPP stably associates with the Golgi and is required for vesicle docking
    Barrowman, J
    Sacher, M
    Ferro-Novick, S
    [J]. EMBO JOURNAL, 2000, 19 (05) : 862 - 869