Multiplolides A and B, new antifungal 10-membered lactones from Xylaria multiplex

被引：101

作者：

Boonphong, S

Kittakoop, P ^{[1
]}

Isaka, M

Pittayakhajonwut, D

Tanticharoen, M

Thebtaranonth, Y

机构：

[1] Naresuan Univ, Fac Sci, Dept Chem, Phitsanulok 65000, Thailand

[2] Natl Sci & Technol Dev Agcy, Natl Ctr Genet Engn & Biotechnol, Bangkok 10400, Thailand

[3] Mahidol Univ, Fac Sci, Dept Chem, Bangkok 10400, Thailand

来源：

JOURNAL OF NATURAL PRODUCTS | 2001年 / 64卷 / 07期

关键词：

D O I：

10.1021/np000291p

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Two new 10-membered lactones, namely, multiplolides A (1) and B (2), were isolated from the broth extract of the fungus Xylaria multiplex BCC 1111. Chemical structures of 1 and 2 were elucidated on the basis of their spectral data. Multiplolides A (1) and B (2) exhibited antifungal activity against Candida albicans with IC50 values of 7 and 2 mug/mL, respectively. Both 1 and 2 were inactive in the screening systems toward the malarial parasite Plasmodium falciparum (at 20 mug/mL) and were not cytotoxic to BC-1 and KB cell lines (at 20 mug/mL).

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页码：965 / 967

页数：3

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