Antidiabetic stilbene and anthraquinone derivatives from Rheum undulatum

被引：81

作者：

Choi, SZ

Lee, SO

Jang, KU

Chung, SH

Park, SH

Kang, HC

Yang, EY

Cho, HJ

Lee, KR

机构：

[1] Sungkyunkwan Univ, Coll Pharm, Nat Prod Lab, Suwon 440746, South Korea

[2] Kyung Hee Univ, Coll Pharm, Pharmacol Lab, Seoul 130701, South Korea

[3] Nat Prod Project, R&D Ctr Pharmaceut Sci & Technol, Ichon 467812, South Korea

来源：

ARCHIVES OF PHARMACAL RESEARCH | 2005年 / 28卷 / 09期

关键词：

Rheum undulatum; Polygonaceae; stilbene; anthraquinone; antidiabetic;

D O I：

10.1007/BF02977396

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The antidiabetic-activity-guided fractionation and isolation of the 80% EtOH extracts obtained from cultivated Korean Rhubarb rhizomes (Rheum undulatum, Polygonaceae) led to the isolation and characterization of one stilbene, desoxyrhapontigenin (1) and two anthraquinones, emodin (2) and chrysophanol (3). Their structures were established by chemical and spectroscopic methods. Compounds 1, 2, and 3 inhibited postprandial hyperglycemia by 35.8, 29.5, 42.3%, respectively.

引用

页码：1027 / 1030

页数：4

共 7 条

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