New therapies for inflammatory bowel disease: from the bench to the bedside

被引：238

作者：

Danese, Silvio ^{[1
]}

机构：

[1] Ist Clin Humanitas, Div Gastroenterol, IBD Ctr, I-20089 Milan, Italy

来源：

GUT | 2012年 / 61卷 / 06期

关键词：

PLACEBO-CONTROLLED TRIAL; ACTIVE CROHNS-DISEASE; ORAL INTERLEUKIN-12/23 INHIBITOR; RECOMBINANT HUMAN INTERLEUKIN-10; ANTIINTERFERON-GAMMA ANTIBODY; HUMANIZED MONOCLONAL-ANTIBODY; COLONY-STIMULATING FACTOR; NECROSIS-FACTOR-ALPHA; PHASE-I TRIAL; ULCERATIVE-COLITIS;

D O I：

10.1136/gutjnl-2011-300904

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

The mechanisms underlying the chronic intestinal inflammation that is a hallmark of inflammatory bowel diseases (IBD) are complex. Components of the pathological response include the adaptive and innate immune systems, as well as the intestinal epithelium and endothelium. Advances in the understanding of the roles of each of these components have resulted in the development of multiple biological agents that all represent an alternative to the use of current therapies in patients with refractory Crohn's disease or ulcerative colitis. This study systematically reviews the mechanisms of action, efficacy and safety of new and emerging therapies that are currently in clinical trials and discusses future directions in the treatment of IBD.

引用

页码：918 / 932

页数：15

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