Relation between the solubility of proteins in aqueous solutions and the second virial coefficient of the solution

被引：151

作者：

Haas, C

Drenth, J

Wilson, WW

机构：

[1] Univ Groningen, Biophys Chem Lab, NL-9747 AG Groningen, Netherlands

[2] Mississippi State Univ, Dept Chem, Mississippi State, MS 39762 USA

来源：

JOURNAL OF PHYSICAL CHEMISTRY B | 1999年 / 103卷 / 14期

关键词：

D O I：

10.1021/jp984035l

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Tn recent publications it was pointed out that there is a correlation between the observed values of the solubility of proteins in aqueous solutions and the second virial coefficient of the solution. In this paper we give a theoretical explanation of this relation. The derived theoretical expression describes the experimentally observed relation between solubility and virial coefficient quite accurately. It is concluded that a variation of the crystallization conditions has little effect on the anisotropy or the range of the interactions between the protein molecules. Analysis of the data for lysozyme indicates a strong anisotropy of the interactions between the molecules.

引用

页码：2808 / 2811

页数：4

共 14 条

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