p85β phosphoinositide 3-kinase subunit regulates tumor progression

被引：63

作者：

Cortes, Isabel ^{[1
]}

Sanchez-Ruiz, Jesus ^{[1
]}

Zuluaga, Susana ^{[1
]}

Calvanese, Vincenzo ^{[1
]}

Marques, Miriam ^{[3
]}

Hernandez, Carmen ^{[1
]}

Rivera, Teresa ^{[4
]}

Kremer, Leonor ^{[2
]}

Gonzalez-Garcia, Ana ^{[1
]}

Carrera, Ana C. ^{[1
]}

机构：

[1] Univ Autonoma Madrid, CSIC, Ctr Nacl Biotecnol, Dept Immunol & Oncol, E-28049 Madrid, Spain

[2] Univ Autonoma Madrid, CSIC, Ctr Nacl Biotecnol, Prot Tools Unit, E-28049 Madrid, Spain

[3] Spanish Natl Canc Res, Dept Mol Pathol, Madrid 28029, Spain

[4] Hosp Univ Mostoles, Human Pathol Serv, Madrid 28935, Spain

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2012年 / 109卷 / 28期

关键词：

PHOSPHATIDYLINOSITOL 3'-KINASE; P85-ALPHA GENE; CANCER; MUTATIONS; CELLS; PTEN;

D O I：

10.1073/pnas.1118138109

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

070301 [无机化学]; 070403 [天体物理学]; 070507 [自然资源与国土空间规划学]; 090105 [作物生产系统与生态工程];

摘要：

PIK3R2 encodes a ubiquitous regulatory subunit (p85 beta) of PI3K, an enzyme that generates 3-polyphosphoinositides at the plasma membrane. PI3K activation triggers cell survival and migration. We found that p85 beta expression is elevated in breast and colon carcinomas and that its increased expression correlates with PI3K pathway activation and tumor progression. p85 beta expression induced moderate PIP3 generation at the cell membrane and enhanced cell invasion. In accordance, genetic alteration of pik3r2 expression levels modulated tumor progression in vivo. Increased p85 beta expression thus represents a cellular strategy in cancer progression.

引用

页码：11318 / 11323

页数：6

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