Correlating rates of cerebral atrophy in Parkinson's disease with measures of cognitive decline

被引:68
作者
Hu, MTM
White, SJ
Chaudhuri, KR
Morris, RG
Bydder, GM
Brooks, DJ
机构
[1] Hammersmith Hosp, Imperial Coll Sch Med, MRC, Ctr Clin Sci, London W12 0NN, England
[2] Hammersmith Hosp, Imperial Coll Sch Med, Div Neurosci, London W12 0NN, England
[3] Hammersmith Hosp, Imperial Coll Sch Med, Robert Steiner MR Unit, London W12 0NN, England
[4] Guys Kings & St Thomas Sch Med, Dept Neurol, Movement Disorders Unit, Inst Neurol, London, England
[5] Univ London Kings Coll, Inst Psychiat, London WC2R 2LS, England
[6] Univ Hosp Lewisham, Lewisham, England
[7] Univ London Kings Coll, Kings Neurosci Ctr, Dept Clin Neuropsychol, London WC2R 2LS, England
[8] Univ London Kings Coll, Inst Psychiat, London WC2R 2LS, England
关键词
atrophy; Parkinson's disease; cognitive;
D O I
10.1007/s007020170057
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
We studied eight clinically non-demented PD patients and ten age-matched controls with serial volumetric T-1-weighted MRI. All PD patients underwent full neuropsychological testing at baseline and follow up scans. Sub-voxel coregistration of the serial MRI scans with quantification of changes in total brain substance and ventricular size per year was performed. The PD patients had significant reductions in both percentage and absolute annual brain volume loss when compared to age-matched controls (p < 0.001). There were significant correlations between reductions in percentage brain volume loss and estimated reductions in performance IQ (r = 0.841, p = 0.004) and full scale IQ (r = 0.63, p = 0.049), measured by subtracting IQ measures at time of follow up scan from premorbid estimates. In conclusion, PD patients have a significant rate of median brain volume loss [10.35 (range) 6.69-16.90ml/year] with no significant loss seen in age-matched controls, and these changes correlate with global measures of cognitive decline. Further longitudinal studies could evaluate whether serial volumetric MRI is a useful technique in predicting the preclinical onset of dementia in Parkinson's disease patients, and its role in the assessment of putative treatments for slowing disease progression.
引用
收藏
页码:571 / 580
页数:10
相关论文
共 31 条
[1]   THE NEW ADULT READING TEST-REVISED - ACCURACY IN ESTIMATING WAIS-R IQ SCORES OBTAINED 3.5 YEARS EARLIER FROM NORMAL OLDER PERSONS [J].
BERRY, DTR ;
CARPENTER, GS ;
CAMPBELL, DA ;
SCHMITT, FA ;
HELTON, K ;
LIPKEMOLBY, T .
ARCHIVES OF CLINICAL NEUROPSYCHOLOGY, 1994, 9 (03) :239-250
[2]   PARKINSON DISEASE, DEMENTIA, AND ALZHEIMER-DISEASE - CLINICOPATHOLOGICAL CORRELATIONS [J].
BOLLER, F ;
MIZUTANI, T ;
ROESSMANN, U ;
GAMBETTI, P .
ANNALS OF NEUROLOGY, 1980, 7 (04) :329-335
[3]   HOW COMMON IS DEMENTIA IN PARKINSONS-DISEASE [J].
BROWN, RG ;
MARSDEN, CD .
LANCET, 1984, 2 (8414) :1262-1265
[4]   The Mackenzie Davidson Memorial Lecture: Detection of small changes to the brain with serial magnetic resonance imaging [J].
Bydder, GM .
BRITISH JOURNAL OF RADIOLOGY, 1995, 68 (816) :1271-1295
[5]  
CHAKOS MH, 1994, AM J PSYCHIAT, V151, P1430
[6]   PREDICTION OF WAIS IQ WITH THE NATIONAL ADULT READING TEST - CROSS-VALIDATION AND EXTENSION [J].
CRAWFORD, JR ;
PARKER, DM ;
STEWART, LE ;
BESSON, JAO ;
DELACEY, G .
BRITISH JOURNAL OF CLINICAL PSYCHOLOGY, 1989, 28 :267-273
[7]  
DELIS DC, 1987, CALIFORNIA VERBAL LE
[8]   MINI-MENTAL STATE - PRACTICAL METHOD FOR GRADING COGNITIVE STATE OF PATIENTS FOR CLINICIAN [J].
FOLSTEIN, MF ;
FOLSTEIN, SE ;
MCHUGH, PR .
JOURNAL OF PSYCHIATRIC RESEARCH, 1975, 12 (03) :189-198
[9]   Serial magnetic resonance imaging of cerebral atrophy in preclinical Alzheimer's disease [J].
Fox, NC ;
Warrington, EK ;
Rossor, MN .
LANCET, 1999, 353 (9170) :2125-2125
[10]   Visualisation and quantification of rates of atrophy in Alzheimer's disease [J].
Fox, NC ;
Freeborough, PA ;
Rossor, MN .
LANCET, 1996, 348 (9020) :94-97