Essential role for estrogen in protection against Vibrio vulnificus-induced endotoxic shock

被引：76

作者：

Merkel, SM ^{[1
]}

Alexander, S ^{[1
]}

Zufall, E ^{[1
]}

Oliver, JD ^{[1
]}

Huet-Hudson, YM ^{[1
]}

机构：

[1] Univ N Carolina, Dept Biol, Charlotte, NC 28223 USA

来源：

INFECTION AND IMMUNITY | 2001年 / 69卷 / 10期

关键词：

D O I：

10.1128/IAI.69.10.6119-6122.2001

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Little is known about the underlying mechanisms that result in a sexually dimorphic response to Vibrio vulnificus endotoxic shock. V. vulnificus is a gram-negative bacterium, considered one of the most invasive and rapidly fatal human pathogens known. However, 85% of individuals that develop endotoxic shock from V. vulnificus are males. Using the rat, we have developed a model for V. vulnificus endotoxic shock that mimics the sexually dimorphic response in humans. Gonadectomy in females results in increased mortality, and estrogen replacement results in decreased mortality in both gonadectomized males and females. These results demonstrate that estrogen is providing protection against V. vulnificus lipopolysaccharide-induced endotoxic shock.

引用

页码：6119 / 6122

页数：4

共 33 条

[1] SEROLOGICAL DIVERSITY AND CHEMICAL STRUCTURES OF CAMPYLOBACTER-JEJUNI LOW-MOLECULAR-WEIGHT LIPOPOLYSACCHARIDES [J].