REVERSAL OF HYPOTENSION INDUCED BY VIBRIO-VULNIFICUS LIPOPOLYSACCHARIDE IN THE RAT BY INHIBITION OF NITRIC-OXIDE SYNTHASE

被引:10
作者
ELMORE, SP
WATTS, JA
SIMPSON, LM
OLIVER, JD
机构
[1] Department of Biology, University of North Carolina at Charlotte, Charlotte
关键词
ENDOTOXIN; LPS; NITRIC OXIDE; VIBRIO; L-NMMA; SHOCK;
D O I
10.1016/0882-4010(92)90082-Y
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Intravenous infusion of Vibrio vulnificus lipopolysaccharide (LPS) (1 mg/kg body wt) in rats caused a dramatic drop in mean arterial pressure within 10 min and a further decline in mean arterial pressure and heart rate which lead to death between 25 and 70 min. Rats treated with LPS followed 10 min later by the intravenous infusion of NG-monomethyl-L-arginine (L-NMMA, 20 mg/kg body wt) showed an initial drop in mean arterial pressure owing to the LPS infusion, followed by a transient rise in mean arterial pressure which lasted for approximately 40 min after the infusion of L-NMMA. The pressure values then remained level for at least 150 min post-LPS infusion. Control rats treated with equivalent volumes of saline infusion showed stable values of mean arterial pressure and heart rate. Additional control rats receiving L-NMMA alone showed the transient rise in mean arterial pressure, followed by a return to the baseline values. The results indicate that the symptoms of endotoxic shock resulting from V. vulnificus LPS may result in part from the stimulation of the activity of nitric oxide synthase. Inhibition of nitric oxide synthase by L-NMMA is a possible treatment for toxic shock induced by V. vulnificus. © 1992.
引用
收藏
页码:391 / 397
页数:7
相关论文
共 28 条
[1]   AN INHIBITOR OF NITRIC-OXIDE PRODUCTION, N(G)-NITRO-L-ARGININE-METHYL ESTER, IMPROVES SURVIVAL IN ANAPHYLACTIC SHOCK [J].
AMIR, S ;
ENGLISH, AM .
EUROPEAN JOURNAL OF PHARMACOLOGY, 1991, 203 (01) :125-127
[2]   ENDOTHELIUM INDEPENDENT PROTECTIVE EFFECT OF NG-MONOMETHYL-L-ARGININE ON ENDOTOXIN-INDUCED ALTERATIONS OF VASCULAR REACTIVITY [J].
AUGUET, M ;
GUILLON, JM ;
DELAFLOTTE, S ;
ETIEMBLE, E ;
CHABRIER, PE ;
BRAQUET, P .
LIFE SCIENCES, 1991, 48 (02) :189-193
[3]   STUDIES ON THE LIPOPOLYSACCHARIDE OF A VIRULENT AND AN AVIRULENT STRAIN OF VIBRIO-VULNIFICUS [J].
BAHRANI, K ;
OLIVER, JD .
BIOCHEMISTRY AND CELL BIOLOGY-BIOCHIMIE ET BIOLOGIE CELLULAIRE, 1990, 68 (02) :547-551
[4]   ENDOTOXIN-INDUCED IMPAIRMENT OF VASCULAR SMOOTH-MUSCLE CONTRACTIONS ELICITED BY DIFFERENT MECHANISMS [J].
BIGAUD, M ;
JULOUSCHAEFFER, G ;
PARRATT, JR ;
STOCLET, JC .
EUROPEAN JOURNAL OF PHARMACOLOGY, 1990, 190 (1-2) :185-192
[5]   NEGATIVE INOTROPIC EFFECTS OF CYTOKINES ON THE HEART MEDIATED BY NITRIC-OXIDE [J].
FINKEL, MS ;
ODDIS, CV ;
JACOB, TD ;
WATKINS, SC ;
HATTLER, BG ;
SIMMONS, RL .
SCIENCE, 1992, 257 (5068) :387-389
[6]   INCUBATION WITH ENDOTOXIN ACTIVATES THE L-ARGININE PATHWAY IN VASCULAR TISSUE [J].
FLEMING, I ;
GRAY, GA ;
JULOUSCHAEFFER, G ;
PARRATT, JR ;
STOCLET, JC .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1990, 171 (02) :562-568
[7]   EVIDENCE THAT AN L-ARGININE NITRIC-OXIDE DEPENDENT ELEVATION OF TISSUE CYCLIC-GMP CONTENT IS INVOLVED IN DEPRESSION OF VASCULAR REACTIVITY BY ENDOTOXIN [J].
FLEMING, I ;
JULOUSCHAEFFER, G ;
GRAY, GA ;
PARRATT, JR ;
STOCLET, JC .
BRITISH JOURNAL OF PHARMACOLOGY, 1991, 103 (01) :1047-1052
[8]   THE EFFECT OF INHIBITORS OF THE L-ARGININE NITRIC-OXIDE PATHWAY ON ENDOTOXIN-INDUCED LOSS OF VASCULAR RESPONSIVENESS IN ANESTHETIZED RATS [J].
GRAY, GA ;
SCHOTT, C ;
JULOUSCHAEFFER, G ;
FLEMING, I ;
PARRATT, JR ;
STOCLET, JC .
BRITISH JOURNAL OF PHARMACOLOGY, 1991, 103 (01) :1218-1224
[9]  
GRAY GA, 1990, CIRC SHOCK, V31, P395
[10]   LOSS OF VASCULAR RESPONSIVENESS INDUCED BY ENDOTOXIN INVOLVES L-ARGININE PATHWAY [J].
JULOUSCHAEFFER, G ;
GRAY, GA ;
FLEMING, I ;
SCHOTT, C ;
PARRATT, JR ;
STOCLET, JC .
AMERICAN JOURNAL OF PHYSIOLOGY, 1990, 259 (04) :H1038-H1043