Cohesion by topology: sister chromatids interlocked by DNA

被引：7

作者：

Bermejo, Rodrigo

Branzei, Dana

Foiani, Marco ^{[1
]}

机构：

[1] Inst Mol Oncol Fdn, FIRC, I-20139 Milan, Italy

来源：

GENES & DEVELOPMENT | 2008年 / 22卷 / 17期

关键词：

sister chromosome cohesion; Escherichia coli; precatenanes; topoisomerase IV;

D O I：

10.1101/gad.1719308

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Sister chromatid cohesion is coupled with chromosome replication and influences chromosome segregation and intra-S repair. Specialized proteins, the cohesins, together with other pathways contribute to tether sister chromatids. In this issue of Genes & Development, Wang and colleagues (pp. 2426-2433) demonstrate that TopoIV, a type II DNA topoisomerase, modulates cohesion in Escherichia coli, by removing interlocked DNA junctions between sister chromatids. They propose that DNA precatenanes, arising during replication fork progression, hold sister chromatids together.

引用

收藏

页码：2297 / 2301

页数：5

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