Prospective evaluation of the International Neuroblastoma Staging System (INSS) and the International Neuroblastoma Response Criteria (INRC) in a multicentre setting

被引:27
作者
Castel, V
García-Miguel, P
Cañete, A
Melero, C
Navajas, A
Ruíz-Jiménez, JI
Navarro, S
Badal, MD
机构
[1] Hosp Infantil La Fe, Paediat Oncol Unit, Valencia 46009, Spain
[2] Hosp Infantil La Paz, Madrid, Spain
[3] Hosp 12 Octubre, E-28041 Madrid, Spain
[4] Hosp Infantil Cruces, Baracaldo, Spain
[5] Hosp Virgen Arrixaca, Dept Paediat Surg, Murcia, Spain
[6] Hosp Clin, Dept Pathol, Valencia, Spain
[7] Hosp La Fe, Serv Radiotherapy, E-46009 Valencia, Spain
关键词
neuroblastoma; INSS; neural crest tumours;
D O I
10.1016/S0959-8049(98)00395-5
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
The aim of this study was to classify prospectively a series of neuroblastoma tumours according to the International Neuroblastoma Staging System (INSS) and the International Neuroblastoma Response Criteria (INRC) and to evaluate the difficulties and pitfalls involved in a multicentre setting. Each hospital provided their data for central review. The surgical procedures and their complications were reported. Kaplan-Meier estimates of survival and event-free survival were calculated according to stage and response to therapy. From June 1992 to December 1996, 194 patients were included in the study, with a mean age of 2 years. Initial studies were performed according to INSS recommendations without major problems. INSS stage was correctly applied to all patients except for 9 (95%). Postoperative complications were observed in 15 patients (8.3%). Response to therapy (INRC) was studied in 63 stage 4 patients, 11 of whom were not classified correctly (17%). Differences in survival according to stage (INSS) and group of response to therapy (INRC) were statistically significant (P < 0.001). In conclusion the INSS was easy to use and separated different prognostic groups. Surgical complications and mortality did not increase in this series because of using the INSS. The feasibility of INRC was evaluated in a small series of stage 4 patients and the designation of response was problematic in a relatively high proportion of cases. The prognostic value of the different responses was highly significant, but less informative than had been hoped for. (C) 1999 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码:606 / 611
页数:6
相关论文
共 21 条
[1]  
AZIZKHAN RG, 1985, SURGERY, V97, P514
[2]   REVISIONS OF THE INTERNATIONAL CRITERIA FOR NEUROBLASTOMA DIAGNOSIS, STAGING, AND RESPONSE TO TREATMENT [J].
BRODEUR, GM ;
PRITCHARD, J ;
BERTHOLD, F ;
CARLSEN, NLT ;
CASTEL, V ;
CASTLEBERRY, RP ;
DEBERNARDI, B ;
EVANS, AE ;
FAVROT, M ;
HEDBORG, F ;
KANEKO, M ;
KEMSHEAD, J ;
LAMPERT, F ;
LEE, REJ ;
LOOK, AT ;
PEARSON, ADJ ;
PHILIP, T ;
ROALD, B ;
SAWADA, T ;
SEEGER, RC ;
TSUCHIDA, Y ;
VOUTE, PA .
JOURNAL OF CLINICAL ONCOLOGY, 1993, 11 (08) :1466-1477
[3]   INTERNATIONAL CRITERIA FOR DIAGNOSIS, STAGING, AND RESPONSE TO TREATMENT IN PATIENTS WITH NEURO-BLASTOMA [J].
BRODEUR, GM ;
SEEGER, RC ;
BARRETT, A ;
BERTHOLD, F ;
CASTLEBERRY, RP ;
DANGIO, G ;
DEBERNARDI, B ;
EVANS, AE ;
FAVROT, M ;
FREEMAN, AI ;
HAASE, G ;
HARTMANN, O ;
HAYES, FA ;
HELSON, L ;
KEMSHEAD, J ;
LAMPERT, F ;
NINANE, J ;
OHKAWA, H ;
PHILIP, T ;
PINKERTON, CR ;
PRITCHARD, J ;
SAWADA, T ;
SIEGEL, S ;
SMITH, EI ;
TSUCHIDA, Y ;
VOUTE, PA .
JOURNAL OF CLINICAL ONCOLOGY, 1988, 6 (12) :1874-1881
[4]   PROGNOSTIC VALUE OF DIFFERENT STAGING SYSTEMS IN NEUROBLASTOMAS AND COMPLETENESS OF TUMOR-EXCISION [J].
CARLSEN, NLT ;
CHRISTENSEN, IJ ;
SCHROEDER, H ;
BRO, PV ;
HESSELBJERG, U ;
JENSEN, KB ;
NIELSEN, OH .
ARCHIVES OF DISEASE IN CHILDHOOD, 1986, 61 (09) :832-842
[5]  
Castel Sanchez V, 1997, An Esp Pediatr, V47, P584
[6]  
Castel Sanchez V, 1993, An Esp Pediatr, V38, P471
[7]   TREATMENT OF STAGE-III NEUROBLASTOMA WITH EMPHASIS ON INTENSIVE INDUCTION CHEMOTHERAPY - A REPORT FROM THE NEUROBLASTOMA GROUP OF THE SPANISH SOCIETY OF PEDIATRIC ONCOLOGY [J].
CASTEL, V ;
BADAL, MD ;
BEZANILLA, JL ;
LLOMBART, A ;
RUIZJIMENEZ, JI ;
DETOLEDO, JS ;
MELERO, C ;
MULET, J .
MEDICAL AND PEDIATRIC ONCOLOGY, 1995, 24 (01) :29-35
[8]  
CASTEL V, 1995, INT J PEDIAT HEM ONC, V2, P255
[9]   THE TREATMENT OF ADVANCED NEUROBLASTOMA - RESULTS OF THE SPANISH NEUROBLASTOMA STUDY-GROUP (SNSG) STUDIES [J].
CASTEL, V ;
GARCIAMIGUEL, P ;
MELERO, C ;
NAVAJAS, A ;
NAVARRO, S ;
MOLINA, J ;
BADAL, MD ;
RUIZJIMENEZ, JI .
EUROPEAN JOURNAL OF CANCER, 1995, 31A (04) :642-645
[10]   THE PEDIATRIC-ONCOLOGY-GROUP EXPERIENCE WITH THE INTERNATIONAL STAGING SYSTEM CRITERIA FOR NEUROBLASTOMA [J].
CASTLEBERRY, RP ;
SHUSTER, JJ ;
SMITH, EI .
JOURNAL OF CLINICAL ONCOLOGY, 1994, 12 (11) :2378-2381