THE TREATMENT OF ADVANCED NEUROBLASTOMA - RESULTS OF THE SPANISH NEUROBLASTOMA STUDY-GROUP (SNSG) STUDIES

被引：17

作者：

CASTEL, V

GARCIAMIGUEL, P

MELERO, C

NAVAJAS, A

NAVARRO, S

MOLINA, J

BADAL, MD

RUIZJIMENEZ, JI

机构：

[1] HOSP LA PAZ,MADRID,SPAIN

[2] HOSP CRUCES,BILBAO,SPAIN

[3] HOSP 12 OCTUBRE,MADRID,SPAIN

[4] HOSP VIRGEN CAMINO,PAMPLONA,SPAIN

[5] HOSP CLIN,DEPT PATHOL,VALENCIA,SPAIN

[6] RADIOTHERAPY HOSP,VALENCIA,SPAIN

[7] PEDIAT SURG HOSP,MURCIA,SPAIN

来源：

EUROPEAN JOURNAL OF CANCER | 1995年 / 31A卷 / 04期

关键词：

NEUROBLASTOMA; STAGE III NEUROBLASTOMA; STAGE IV NEUROBLASTOMA; ABMT;

D O I：

10.1016/0959-8049(95)00072-Q

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The Spanish Neuroblastoma Study Group has conducted a study on advanced neuroblastoma (N-I-87), which included 33 stage III and 60 stage IV neuroblastoma children more than 1 year of age, enrolled between October 1987 and April 1992. They were staged according to Evans and treated with induction chemotherapy (IC) consisting of 3 courses of cyclophosphamide-doxorubicin alternating with 3 of high-dose cisplatin-teniposide. Evaluation after IC and surgery demonstrated an overall response rate of 88% for stage III and 69% for stage IV. In the latter, complete responses and good partial responses were 33 and 14%, respectively. After surgery, children received maintenance chemotherapy (all stage III except 2 and 30 stage IV) or autologous bone marrow transplantation (ABMT) (11 stage IV), the distribution was not randomised. Probability of survival at 5 years was 0.60 +/- 0.12 for stage III and 0.24 +/- 0.07 for stage IV. A significant difference in survival at 5 years was found between ''good responders'' and ''non-responders'' to initial chemotherapy.

引用

页码：642 / 645

页数：4

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