Hyperhomocysteinaemia induced by dietary folate restriction causes kidney oxidative stress in rats

被引:15
作者
Díez, N
Pérez, R
Hurtado, V
Santidrián, S
机构
[1] Univ Navarra, Sch Med, Dept Human Physiol, E-31080 Pamplona, Spain
[2] Univ Navarra, Sch Med, Lab Thrombosis & Hemostasia, E-31080 Pamplona, Spain
关键词
homocysteine; folic acid; oxidative stress; kidney;
D O I
10.1079/BJN20051468
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Diet is the most common cause of mild hyperhomocysteinaemia (HHcy), which occurs in approximately 5-7 % of the general population. Since HHcy causes endothelial damage by oxidative stress in different organs, the present study was designed to examine whether HHcy might be involved in renal oxidative stress. Twenty-five male Wistar rats were randomly divided into two groups: one (n 13) was fed ad libitum a folate-free diet (FF) and the other (n 12) was fed the same diet supplemented with folic acid (control, CO). After 8 weeks the animals were killed and kidneys removed. Malondialdehyde (MDA), superoxide dismutase (SOD) and glutathione peroxidase (GPx) activities were measured in plasma and kidney homogenates. Renal tissue sections were analysed by indirect immunostaining with the primary antibody against oxidatively modified LDL receptor (LOX-1). A marked HHcy was confirmed in the FF group. As compared with CO animals, MDA levels in plasma and kidney homogenate were significantly higher in FF rats (P < 0.05). Similarly, renal GPx and SOD activities were significantly higher in the FF group (P < 0.001). No differences were found in LOX-1 immunohistochemical expression, which in the two groups was displayed in tubular cells. The present study provides evidence that HHcy does produce renal oxidative stress mediated by lipid peroxidation, and that the increased kidney MDA displayed by FF animals may enhance kidney antioxidant activity and thereby attenuate both kidney damage and expression of LOX-1.
引用
收藏
页码:204 / 210
页数:7
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