The 2011 Report on Dietary Reference Intakes for Calcium and Vitamin D from the Institute of Medicine: What Clinicians Need to Know

被引：2992

作者：

Ross, A. Catharine ^{[1
]}

Manson, JoAnn E. ^{[2
]}

Abrams, Steven A. ^{[3
]}

Aloia, John F. ^{[4
,5
]}

Brannon, Patsy M. ^{[6
]}

Clinton, Steven K. ^{[7
]}

Durazo-Arvizu, Ramon A. ^{[8
]}

Gallagher, J. Christopher ^{[9
]}

Gallo, Richard L. ^{[10
]}

Jones, Glenville ^{[11
]}

Kovacs, Christopher S. ^{[12
]}

Mayne, Susan T. ^{[13
]}

Rosen, Clifford J. ^{[14
]}

Shapses, Sue A. ^{[15
]}

机构：

[1] Penn State Univ, Dept Nutr Sci, Chandlee Lab 110, University Pk, PA 16802 USA

[2] Harvard Univ, Brigham & Womens Hosp, Sch Med, Dept Med, Boston, MA 02215 USA

[3] Baylor Coll Med, Dept Pediat, Houston, TX 77030 USA

[4] SUNY Stony Brook, Dept Med, Stony Brook, NY 11794 USA

[5] Winthrop Univ Hosp, Mineola, NY 11501 USA

[6] Cornell Univ, Div Nutr Sci, Ithaca, NY 14853 USA

[7] Ohio State Univ, Div Hematol & Oncol, Columbus, OH 43210 USA

[8] Loyola Univ, Stritch Sch Med, Dept Epidemiol & Prevent Med, Maywood, IL 60153 USA

[9] Creighton Univ, Med Ctr, Bone Metab Unit, Omaha, NE 68131 USA

[10] Univ Calif San Diego, Dept Med, La Jolla, CA 92093 USA

[11] Queens Univ, Dept Biochem, Kingston, ON K7L 3N6, Canada

[12] Mem Univ Newfoundland, Fac Med Endocrinol, St John, NF A1B 3V6, Canada

[13] Yale Univ, Sch Publ Hlth, Dept Epidemiol & Publ Hlth, New Haven, CT 06520 USA

[14] Maine Med Ctr, Res Inst, Ctr Clin & Translat Med, Scarborough, ME 04074 USA

[15] Rutgers State Univ, Dept Nutr Sci, New Brunswick, NJ 08901 USA

来源：

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM | 2011年 / 96卷 / 01期

关键词：

CARDIOVASCULAR-DISEASE; RISK; CANCER; 25-HYDROXYVITAMIN-D; MORTALITY;

D O I：

10.1210/jc.2010-2704

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

This article summarizes the new 2011 report on dietary requirements for calcium and vitamin D from the Institute of Medicine (IOM). An IOM Committee charged with determining the population needs for these nutrients in North America conducted a comprehensive review of the evidence for both skeletal and extraskeletal outcomes. The Committee concluded that available scientific evidence supports a key role of calcium and vitamin D in skeletal health, consistent with a cause-and-effect relationship and providing a sound basis for determination of intake requirements. For extraskeletal outcomes, including cancer, cardiovascular disease, diabetes, and autoimmune disorders, the evidence was inconsistent, inconclusive as to causality, and insufficient to inform nutritional requirements. Randomized clinical trial evidence for extraskeletal outcomes was limited and generally uninformative. Based on bone health, Recommended Dietary Allowances (RDAs; covering requirements of 97.5% of the population) for calcium range from 700 to 1300 mg/d for life-stage groups at least 1 yr of age. For vitamin D, RDAs of 600 IU/d for ages 1-70 yr and 800 IU/d for ages 71 yr and older, corresponding to a serum 25-hydroxyvitamin D level of at least 20 ng/ml (50 nmol/liter), meet the requirements of at least 97.5% of the population. RDAs for vitamin D were derived based on conditions of minimal sun exposure due to wide variability in vitamin D synthesis from ultraviolet light and the risks of skin cancer. Higher values were not consistently associated with greater benefit, and for some outcomes U-shaped associations were observed, with risks at both low and high levels. The Committee concluded that the prevalence of vitamin D inadequacy in North America has been overestimated. Urgent research and clinical priorities were identified, including reassessment of laboratory ranges for 25-hydroxyvitamin D, to avoid problems of both undertreatment and overtreatment. (J Clin Endocrinol Metab 96: 53-58, 2011)

引用

页码：53 / 58

页数：6

共 11 条

[11] Vitamin D deficiency and risk of cardiovascular disease [J].

Wang, Thomas J. ;

Pencina, Michael J. ;

Booth, Sarah L. ;

Jacques, Paul F. ;

Ingelsson, Erik ;

Lanier, Katherine ;

Benjamin, Emelia J. ;

D'Agostino, Ralph B. ;

Wolf, Myles ;

Vasan, Ramachandran S. .

CIRCULATION, 2008, 117 (04) :503-511

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