Identification using LC-MSn of co-metabolites in the biosynthesis of the polyketide toxin mycolactone by a clinical isolate of Mycobacterium ulcerans

被引：40

作者：

Hong, H

Gates, PJ

Staunton, J

Stinear, T

Cole, ST

Leadlay, PF

Spencer, JB

机构：

[1] Univ Cambridge, Dept Chem, Cambridge CB2 1EW, England

[2] Univ Cambridge, Dept Biochem, Cambridge CB2 1QW, England

[3] Inst Pasteur, Unite Genet Mol Bacterienne, F-75015 Paris, France

来源：

CHEMICAL COMMUNICATIONS | 2003年 / 22期

关键词：

D O I：

10.1039/b308163j

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

LC-MSn analysis of mycolactone toxin from extracts of Mycobacterium ulcerans has shown that minor co-metabolites, including two previously unreported, differ structurally from mycolactone only in a small portion of the polyketide side-chain.

引用

页码：2822 / 2823

页数：2

共 9 条

[1] Stereochemistry of the core structure of the mycolactones [J].

Benowitz, AB ;

Fidanze, S ;

Small, PLC ;

Kishi, Y .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2001, 123 (21) :5128-5129

[2] Suspension cultivation of Mycobacterium ulcerans for the production of mycolactones [J].

Cadapan, LD ;

Arslanian, RL ;

Carney, JR ;

Zavala, SM ;

Small, PL ;

Licari, P .

FEMS MICROBIOLOGY LETTERS, 2001, 205 (02) :385-389

[3] Complete structure of the mycolactones [J].

Fidanze, S ;

Song, FB ;

Szlosek-Pinaud, M ;

Small, PLC ;

Kishi, Y .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2001, 123 (41) :10117-10118

[4] Mycolactone:: A polyketide toxin from Mycobacterium ulcerans required for virulence [J].

George, KM ;

Chatterjee, D ;

Gunawardana, G ;

Welty, D ;

Hayman, J ;

Lee, R ;

Small, PLC .

SCIENCE, 1999, 283 (5403) :854-857

[5] A Mycobacterium ulcerans toxin, mycolactone, causes apoptosis in guinea pig ulcers and tissue culture cells [J].

George, KM ;

Pascopella, L ;

Welty, DM ;

Small, PLC .

INFECTION AND IMMUNITY, 2000, 68 (02) :877-883

[6] Characterization of novel macrolide toxins, mycolactones A and B, from a human pathogen, Mycobacterium ulcerans [J].

Gunawardana, G ;

Chatterjee, D ;

George, KM ;

Brennan, P ;

Whittern, D ;

Small, PLC .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1999, 121 (25) :6092-6093

[7] Heterogeneity of mycolactones produced by clinical isolates of Mycobacterium ulcerans:: Implications for virulence [J].

Mve-Obiang, A ;

Lee, RE ;

Portaels, F ;

Small, PLC .

INFECTION AND IMMUNITY, 2003, 71 (02) :774-783

[8]

Rohr J, 2000, ANGEW CHEM INT EDIT, V39, P2847, DOI 10.1002/1521-3773(20000818)39:16<2847::AID-ANIE2847>3.0.CO

[9]

2-0

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