X-ray structures and analysis of 11 cyclosporin derivatives complexed with cyclophilin A

被引：62

作者：

Kallen, J ^{[1
]}

Mikol, V ^{[1
]}

Taylor, P ^{[1
]}

Walkinshaw, MD ^{[1
]}

机构：

[1] Univ Edinburgh, Struct Biochem Grp, Edinburgh EH9 3JR, Midlothian, Scotland

来源：

JOURNAL OF MOLECULAR BIOLOGY | 1998年 / 283卷 / 02期

关键词：

immunophilin; cyclosporin A; cyclophilin; ligand binding; molecular recognition;

D O I：

10.1006/jmbi.1998.2108

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Eight new X-ray structures of different cyclophilin A/cyclosporin-derivative complexes are presented. These structures, combined with the existing three published cyclosporin complexes, provide a useful structural database for the analysis of protein-ligand interactions. The effect of small chemical differences on protein-ligand hydrogen-bonding, van der Waals interactions and water structure is presented. (C) 1998 Academic Press.

引用

页码：435 / 449

页数：15

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