Impact of Preterm PROM and its Complications on Long-term Infant Outcomes

被引：55

作者：

Clark, Erin A. S. ^{[1
]}

Varner, Michael ^{[1
]}

机构：

[1] Univ Utah, Sch Med, Dept Obstet & Gynecol, Salt Lake City, UT 84112 USA

来源：

CLINICAL OBSTETRICS AND GYNECOLOGY | 2011年 / 54卷 / 02期

关键词：

cerebral palsy; neurodevelopmental delay; preterm birth; preterm premature rupture of membranes (PPROM); FETAL INFLAMMATORY RESPONSE; PREMATURE RUPTURE; ANTENATAL CORTICOSTEROIDS; MAGNESIUM-SULFATE; CEREBRAL-PALSY; FOLLOW-UP; MEMBRANES; BIRTH; INTERLEUKIN-6; ANTIBIOTICS;

D O I：

10.1097/GRF.0b013e318217ee18

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

There is increasing evidence that preterm premature rupture of membranes (PPROM) is associated with increased risk for adverse neurodevelopmental outcomes through multiple mechanisms, including preterm birth and its antecedent etiologies. Intrauterine infection is a particularly important risk factor for adverse neurodevelopmental outcomes after PPROM. This review focuses on the long-term neurodevelopmental outcomes after PPROM, the possible etiologic mechanisms of neurological injury, and the effect of antenatal and perinatal interventions using available evidence.

引用

页码：358 / 369

页数：12

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