Spiruchostatins A and B, novel gene expression-enhancing substances produced by Pseudomonas sp.

被引:98
作者
Masuoka, Y
Nagai, A
Shin-ya, K [1 ]
Furihata, K
Nagai, K
Suzuki, K
Hayakawa, Y
Seto, H
机构
[1] Univ Tokyo, Inst Mol & Cellular Biosci, Bunkyo Ku, Tokyo 1130032, Japan
[2] Univ Tokyo, Grad Sch Agr & Life Sci, Bunkyo Ku, Tokyo 1138657, Japan
[3] Yamanouchi Pharmaceut Co Ltd, Inst Drug Discovery Res, Microbiol Labs, Itabashi Ku, Tokyo 1748511, Japan
基金
日本学术振兴会;
关键词
spiruchostatin; bicyclic depsipeptide; Pseudomonas;
D O I
10.1016/S0040-4039(00)01874-8
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
Spiruchostatins A and B were isolated from Pseudomonas sp. as gene expression-enhancing substances. They possess novel bicyclic depsipeptides involving 4-amino-3-hydroxy-5-methylhexanoic acid and 4-amino-3-hydroxy-5-melhylheptanoic acid residues, respectively, as shown in Fig. 1. (C) 2000 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码:41 / 44
页数:4
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