Enterohaemorrhagic Escherichia coli:: emerging issues on virulence and modes of transmission

被引:462
作者
Caprioli, A
Morabito, S
Brugère, H
Oswald, E
机构
[1] Ist Super Sanita, Dipartimento Sanita Alimentare & Anim, I-00161 Rome, Italy
[2] Ecole Natl Vet Toulouse, UMR INRA Interact Hotes Agents Pathogenes 1225, F-31076 Toulouse, France
关键词
enterohemorrhagic E. coli; E. coli O157; Shiga toxins; foodborne zoonoses;
D O I
10.1051/vetres:2005002
中图分类号
S85 [动物医学(兽医学)];
学科分类号
0906 ;
摘要
Enterohaemorrhagic Escherichia coli ( EHEC) constitute a subset of serotypes ( E. coli O157 and some other serogroups) of Shiga toxin ( Stx)-producing E. coli (STEC) firmly associated with severe human illnesses like bloody diarrhoea and haemolytic uraemic syndrome. Stx production is essential but not sufficient for EHEC virulence. Most strains are capable of colonising the intestinal mucosa of the host with the "attaching and effacing" mechanism, genetically governed by a large pathogenicity island ( PAI) defined as the Locus of Enterocyte Effacement. Other virulence factors carried by mobile genetic elements like PAI and plasmids have been recently described, and their role in the pathogenic process has not been fully elucidated. EHEC are zoonotic pathogens. They rarely cause disease in animals, and ruminants are recognised as their main natural reservoir. Cattle are considered to be the most important source of human infections with EHEC O157, and the ecology of the organism in cattle farming has been extensively studied. The organism has also been reported in sheep, goats, water buffalos, and deer. Pigs and poultry are not considered to be a source of EHEC and the sporadic reports may derive from accidental exposure to ruminant dejections. The epidemiology of EHEC infections has remarkably changed during the past ten years and an increasing number of unusual food vehicles have been associated with human infections. New routes of transmission have emerged, like contact with animals during farm visits and a wide variety of environment-related exposures. As for other zoonotic agents, having animals and raw products that are free from EHEC is not possible in practice. However, their occurrence can be minimised by applying high standards of hygiene in all the steps of the food production chain.
引用
收藏
页码:289 / 311
页数:23
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共 190 条
  • [81] Fate of Escherichia coli O157:H7 in manure-amended soil
    Jiang, XP
    Morgan, J
    Doyle, MP
    [J]. APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 2002, 68 (05) : 2605 - 2609
  • [82] Escherichia coli O157:H7 in faeces from cattle, sheep and pigs in the southwest part of Norway during 1998 and 1999
    Johnsen, G
    Wasteson, Y
    Heir, E
    Berget, OI
    Herikstad, H
    [J]. INTERNATIONAL JOURNAL OF FOOD MICROBIOLOGY, 2001, 65 (03) : 193 - 200
  • [83] Persistence of verocytotoxin-producing Escherichia coli O157:H7 in calves kept on pasture and in calves kept indoors during the summer months in a Swedish dairy herd
    Jonsson, ME
    Aspán, A
    Eriksson, E
    Vågsholm, I
    [J]. INTERNATIONAL JOURNAL OF FOOD MICROBIOLOGY, 2001, 66 (1-2) : 55 - 61
  • [84] Plant cell-based intimin vaccine given orally to mice primed with intimin reduces time of Escherichia coli O157:H7 shedding in feces
    Judge, NA
    Mason, HS
    O'Brien, AD
    [J]. INFECTION AND IMMUNITY, 2004, 72 (01) : 168 - 175
  • [85] A genomic island, termed high-pathogenicity island, is present in certain non-O157 shiga toxin-producing Escherichia coli clonal lineages
    Karch, H
    Schubert, S
    Zhang, D
    Zhang, W
    Schmidt, H
    Ölschlager, T
    Hacker, J
    [J]. INFECTION AND IMMUNITY, 1999, 67 (11) : 5994 - 6001
  • [86] An outbreak of Escherichia coli O157:H7 infections traced to jerky made from deer meat
    Keene, WE
    Sazie, E
    Kok, J
    Rice, DH
    Hancock, DD
    Balan, VK
    Zhao, T
    Doyle, MP
    [J]. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1997, 277 (15): : 1229 - 1231
  • [87] Targeting of an enteropathogenic Escherichia coli (EPEC) effector protein to host mitochondria
    Kenny, B
    Jepson, M
    [J]. CELLULAR MICROBIOLOGY, 2000, 2 (06) : 579 - 590
  • [88] Enteropathogenic E-coli (EPEC) transfers its receptor for intimate adherence into mammalian cells
    Kenny, B
    DeVinney, R
    Stein, M
    Reinscheid, DJ
    Frey, EA
    Finlay, BB
    [J]. CELL, 1997, 91 (04) : 511 - 520
  • [89] A large toxin from pathogenic Escherichia coli strains that inhibits lymphocyte activation
    Klapproth, JA
    Scaletsky, ICA
    McNamara, BP
    Lai, LC
    Malstrom, C
    James, SP
    Donnenberg, MS
    [J]. INFECTION AND IMMUNITY, 2000, 68 (04) : 2148 - 2155
  • [90] Prevalence and characteristics of Shiga toxin-producing Escherichia coli from healthy cattle in Japan
    Kobayashi, H
    Shimada, J
    Nakazawa, M
    Morozumi, T
    Pohjanvirta, T
    Pelkonen, S
    Yamamoto, K
    [J]. APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 2001, 67 (01) : 484 - 489