Dimeric L-Dopa derivatives as potential prodrugs

被引：31

作者：

Di Stefano, A ^{[1
]}

Mosciatti, B

Cingolani, GM

Giorgioni, G

Ricciutelli, M

Cacciatore, I

Sozio, P

Claudi, F

机构：

[1] Univ G DAnnunzio, Dipartimento Sci Farmaco, I-66100 Chieti, Italy

[2] Univ Camerino, Dipartimento Sci Chim, I-62032 Camerino, Italy

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2001年 / 11卷 / 08期

关键词：

D O I：

10.1016/S0960-894X(01)00140-8

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of dimeric derivatives ( +)-1, and ( +)-2. and (+)-3a-d of L-Dopa diacetyl esters was synthesized and evaluated as potential L-Dopa prodrugs with improved physicochemical properties. All the new compounds showed chemical stability in aqueous buffer solutions (pH 1.3 and 7.4). A relatively slow release of r-Dopa in human plasma was observed. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：1085 / 1088

页数：4

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