Phylogenetic analysis and evolution of aromatic amino acid hydroxylase

被引：28

作者：

Cao, Jun ^{[1
]}

Shi, Feng ^{[2
]}

Liu, Xiaoguang ^{[1
]}

Huang, Guang ^{[1
]}

Zhou, Min ^{[1
]}

机构：

[1] Jiangsu Univ, Inst Life Sci, Zhenjiang 212013, Jiangsu, Peoples R China

[2] Shandong Lvdu Biotech Ind, Binzhou 256600, Shandong, Peoples R China

来源：

FEBS LETTERS | 2010年 / 584卷 / 23期

关键词：

Aromatic amino acid hydroxylase; Phylogenetic analysis; Evolution; PHENYLALANINE-HYDROXYLASE; TRYPTOPHAN-HYDROXYLASE; TYROSINE-HYDROXYLASE; LARGE-SCALE; GENE; BINDING; SUBSTITUTION; SELECTION; MODELS; BRAIN;

D O I：

10.1016/j.febslet.2010.11.005

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A study was performed to investigate the phylogenetic relationship among AAAH members and to statistically evaluate sequence conservation and functional divergence. In total, 161 genes were identified from 103 species. Phylogenetic analysis showed that well-conserved subfamilies exist. Exon-intron structure analysis showed that the gene structures of AAAH were highly conserved across some different lineage species, while some species-specific introns were also found. The dynamic distribution of ACT domain suggested one gene fusion event has occurred in eukaryota. Significant functional divergence was found between some subgroups. Analysis of the site-specific profiles revealed critical amino acid residues for functional divergence. This study highlights the molecular evolution of this family and may provide a starting point for further experimental verifications. (c) 2010 Published by Elsevier B.V. on behalf of the Federation of European Biochemical Societies.

引用

页码：4775 / 4782

页数：8

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