Fatty acid incorporation depicts brain activity in a rat model of Parkinson's disease

被引：20

作者：

Hayakawa, T

Chang, MCJ

Bell, JM

Seeman, R

Rapoport, SI

Appel, NM

机构：

[1] US FDA, Ctr Drug Evaluat & Res, Off Testing & Res, Div Appl Pharmacol Res, Laurel, MD 20708 USA

[2] NIA, Neurosci Lab, NIH, Bethesda, MD 20892 USA

[3] Tokyo Med & Dent Univ, Dept Neurosurg, Bunkyo Ku, Tokyo 113, Japan

来源：

BRAIN RESEARCH | 1998年 / 807卷 / 1-2期

关键词：

arachidonic acid; autoradiography; basal ganglia; brain metabolism; fatty acid; functional brain imaging; 6-hydroxydopamine; Parkinson's disease; phospholipase A(2);

D O I：

10.1016/S0006-8993(98)00751-3

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Following pulse labeling with [H-3]arachidonic acid ([H-3]AA), its incorporation pattern in brain reflects regional changes in neurotransmitter signal transduction using phospholipase A(2). that is, functional activity. In a rat model of Parkinson's disease, unilateral 6-hydroxydopamine lesion in the substantia nigra, [H-3]AA acid incorporation from blood was increased in cerebral cortex, caudate putamen, globus pallidus, entopeduncular nucleus, subthalamic nucleus and substantia nigra pars reticulata ipsilateral to the lesion. This increased [H-3]AA incorporation likely reflects disinhibition of basal ganglia and cortical circuits secondary to absent inhibitory nigrostriatal dopaminergic input. (C) 1998 Elsevier Science B.V. All rights reserved.

引用

页码：177 / 181

页数：5

共 25 条

[1] Sequelae of parenteral domoic acid administration in rats: Comparison of effects on different metabolic markers in brain [J].