Anti-inflammatory effects of Mao-Bushi-Saishin-to in mice and rats

被引：10

作者：

Ikeda, Y ^{[1
]}

Iijima, OT ^{[1
]}

Iizuka, A ^{[1
]}

Ishige, A ^{[1
]}

Amagaya, S ^{[1
]}

Komatsu, Y ^{[1
]}

Okada, M ^{[1
]}

Abe, C ^{[1
]}

Fujihira, E ^{[1
]}

机构：

[1] Tsumura & Co, Cent Res Labs, Ami, Ibaraki 3001192, Japan

来源：

AMERICAN JOURNAL OF CHINESE MEDICINE | 1998年 / 26卷 / 02期

关键词：

D O I：

10.1142/S0192415X98000221

中图分类号：

R [医药、卫生];

学科分类号：

10 ;

摘要：

Effects of Mao-Bushi-Saishin-to (MBS) on anti-inflammatory activities were examined in mice and rats. MBS significantly inhibited the increase in vascular permeability induced by acetic acid, the ear edema induced by arachidonic acid and phorbol ester, and the cutaneous extravasation induced by bradykinin and histamine. MBS, however, was not effective against the serotonin-induced cutaneous permeability increase in mice. MBS significantly inhibited carrageenin-induced hind foot edema and cotton pellet-induced granulation tissue growth in rats. These results show that MBS may exert anti-inflammatory effects through the underlying mechanism(s) of preventing mediator release from mast cells and macrophages.

引用

页码：171 / 179

页数：9

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