A piece in the puzzle: an ion channel candidate gene for schizophrenia

被引：33

作者：

Gargus, JJ ^{[1
]}

Fantino, E

Gutman, GA

机构：

[1] Univ Calif Irvine, Dept Physiol & Biophys, Irvine, CA 92697 USA

[2] Univ Calif Irvine, Dept Pediat, Div Human Genet, Irvine, CA 92697 USA

[3] Univ Calif Irvine, Dept Microbiol & Mol Genet, Irvine, CA 92697 USA

来源：

MOLECULAR MEDICINE TODAY | 1998年 / 4卷 / 12期

关键词：

D O I：

10.1016/S1357-4310(98)01358-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Mutations in ion channels have been found to cause a variety of mendelian genetic diseases, and polyglutamine repeat expansion is a newly recognized pathogenic mechanism that causes several rare, genetic, late- onset neurological syndromes. Polymorphic polyglutamine tracts are present in a recently described human, calcium-activated potassium channel, KCNN3 (also known as hKCa3), and alleles of this gene that contain longer repeats have been associated with schizophrenia. The physiological function of the channel is consistent with an etiological role in this disease; drugs designed to target this channel might therefore provide novel psychotherapeutics.

引用

页码：518 / 524

页数：7