Anxiogenesis induced by nitric oxide synthase inhibition and anxiolytic effect of melanin-concentrating hormone (MCH) in rat brain.

被引：71

作者：

Monzón, ME ^{[1
]}

Varas, MM ^{[1
]}

De Barioglio, SR ^{[1
]}

机构：

[1] Univ Nacl Cordoba, Fac Ciencias Quim, Dept Farmacol, Lab Fisiol, RA-5000 Cordoba, Argentina

来源：

PEPTIDES | 2001年 / 22卷 / 07期

关键词：

D O I：

10.1016/S0196-9781(01)00439-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In this study, the involvement of nitric oxide (NO) in the mechanism of anxiety was investigated. The rats: received an intraamygdaline or intrahippocampal injection of the nitric oxide synthase inhibitor, N-G-nitro-1-arginine (L-NOARG), and were then tested in the plus-maze test. L-NOARG induced a decrease in the time spent by rats in the open arms. Conversely, the administration of the melanin-concentrating hormone (MCH) into these structures increased the number of entries into the open arms as well as the time spent on them. MCH injected in rats pretreated with L-NOARG also was able to revert the anxiogenic effects of L-NOARG in amygdala. (C) 2001 Elsevier Science Inc. All rights reserved.

引用

页码：1043 / 1047

页数：5

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